Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | HTR2B | P41595 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5957135 | 0.88 | DRD2 (0.51) | ALDH1A1SMN1; SMN2DRD2DRD4DRD3 | |
| SCHEMBL5957113 | 0.83 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2DRD2HTR2AHTR2B | |
| SCHEMBL5957061 | 0.82 | MAPT (0.49) | SMN1; SMN2DRD2HTR2AHTR2BHTR1A | |
| SCHEMBL5957093 | 0.81 | DRD2 (0.42) | ALDH1A1DRD2HTR2AHTR2BDRD4 | |
| SCHEMBL5957067 | 0.79 | DRD2 (0.41) | ALDH1A1DRD2HTR2AHTR2BDRD4 | |
| SCHEMBL5957097 | 0.79 | DRD2 (0.41) | ALDH1A1DRD2HTR2AHTR2BDRD4 | |
| SCHEMBL5957129 | 0.78 | ADRA1D (0.41) | ALDH1A1DRD2HTR2AHTR2BHTR1A | |
| SCHEMBL5957116 | 0.78 | DRD2 (0.52) | ALDH1A1SMN1; SMN2DRD2HTR2AHTR2B | |
| SCHEMBL5957050 | 0.78 | DRD2 (0.52) | ALDH1A1SMN1; SMN2DRD2DRD4DRD3 | |
| SCHEMBL5957079 | 0.78 | DRD2 (0.40) | ALDH1A1SMN1; SMN2DRD2HTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1726592-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth a Corporation of the State of Delaware (US) | 2006-11-29 | — | — | EP | claimed |
| EP-1375503-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth (US) | 2004-01-02 | — | — | EP | claimed |
| EP-0771800-A2 | Dioxino derivatives and their use as dopamine agonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-07 | — | — | EP | claimed |
| EP-1726592-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth a Corporation of the State of Delaware (US) | 2006-11-29 | — | — | EP | disclosed |
| EP-1375503-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth (US) | 2004-01-02 | — | — | EP | disclosed |
| EP-0771800-A2 | Dioxino derivatives and their use as dopamine agonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-07 | — | — | EP | disclosed |