Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 15/20 | 0.75 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5957389 | 0.91 | TRPA1 (0.80) | TRPA1MAPTSMN1; SMN2 | |
| SCHEMBL5957336 | 0.91 | TRPA1 (0.65) | TRPA1MAPTSMN1; SMN2 | |
| SCHEMBL5957340 | 0.91 | TRPA1 (0.74) | TRPA1SMN1; SMN2 | |
| SCHEMBL5957547 | 0.88 | TRPA1 (0.86) | TRPA1 | |
| SCHEMBL5957282 | 0.87 | TRPA1 (0.84) | TRPA1MAPT | |
| SCHEMBL5957284 | 0.86 | TRPA1 (0.80) | TRPA1MAPT | |
| SCHEMBL5957503 | 0.86 | TRPA1 (1.00) | TRPA1MAPT | |
| SCHEMBL5957305 | 0.85 | TRPA1 (0.71) | TRPA1MAPTS1PR3 | |
| Hydrochloric Acid SCHEMBL5957302 | 0.85 | TRPA1 (0.70) | TRPA1MAPTS1PR3 | |
| Hydrochloric Acid SCHEMBL5957637 | 0.84 | TRPA1 (0.81) | TRPA1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060040957-A1 | BICYCLIC PYRIMIDINE MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY | 2006-02-23 | — | — | US | disclosed |
| EP-1362054-A1 | BICYCLIC PYRIMIDINE MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002064599-A1 | BICYCLIC PYRIMIDINE MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060040957-A1 | BICYCLIC PYRIMIDINE MATRIX METALLOPROTEINASE INHIBITORS | MMP13, MMP25, MMP15 | TRPA1 3405/4885MAPT 4608/4885SMN1; SMN2 1727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.