Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | CFD | P00746 | 1/20 | 0.33 |
| ▸ | ZAP70 | P43403 | 11/20 | 0.32 |
| ▸ | KARS1 | Q15046 | 10/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.31 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.31 |
| ▸ | ATP4A | P20648 | 1/20 | 0.31 |
| ▸ | ATP4B | P51164 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5959155 | 0.84 | POLB (0.39) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4333030 | 0.79 | KMT2A (0.34) | KMT2ARXFP1ZAP70KARS1SYK | |
| SCHEMBL13236218 | 0.77 | ALDH1A1 (0.37) | KMT2ARXFP1ZAP70KARS1CYP4F2 | |
| SCHEMBL2945205 | 0.76 | GABRP (0.38) | KMT2ARXFP1CFDZAP70KARS1 | |
| SCHEMBL13236205 | 0.70 | NPSR1 (0.37) | KMT2ARXFP1ZAP70KARS1 | |
| SCHEMBL12415747 | 0.70 | TLR7 (0.34) | KMT2ARXFP1ZAP70KARS1SYK | |
| SCHEMBL2942781 | 0.69 | PTGDR2 (0.36) | KMT2ARXFP1ZAP70KARS1 | |
| SCHEMBL31738271 | 0.65 | CYP3A4 (0.39) | KMT2ARXFP1PDE4APDE4BPDE4C | |
| SCHEMBL1648730 | 0.61 | CYP3A4 (0.42) | KMT2ARXFP1TSHRCYP19A1 | |
| SCHEMBL28021725 | 0.61 | ADORA2A (0.38) | CFDTSHRCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718649-A2 | IMIDAZO 1,2-C PYRIMIDINYLACETIC ACID DERIVATIVES | Actimis Pharmaceuticals, Inc., (US) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005073234-A2 | IMIDAZO[1,2-C]PYRIMIDINYLACETIC ACID DERIVATIVES | ACTIMIS PHARMACEUTICALS, INC. (US) | 2005-08-11 | — | — | WO | disclosed |