Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11775647 | 0.76 | SMN1; SMN2 (0.47) | HPGDHSD17B10NPSR1POLBSMN1; SMN2 | |
| SCHEMBL564993 | 0.74 | SMN1; SMN2 (0.46) | HPGDHSD17B10NPSR1POLBSMN1; SMN2 | |
| SCHEMBL14221817 | 0.74 | MAPT (0.53) | HPGDHSD17B10NPSR1POLBGAA | |
| SCHEMBL11000015 | 0.73 | KDM4E (0.45) | HPGDHSD17B10NPSR1POLBSMN1; SMN2 | |
| SCHEMBL4289304 | 0.71 | MAPT (0.56) | HPGDHSD17B10NPSR1SMN1; SMN2GAA | |
| SCHEMBL4544224 | 0.69 | SMN1; SMN2 (0.64) | SMN1; SMN2GAAKDM4ETSHRLMNA | |
| SCHEMBL7834516 | 0.69 | HPGD (0.54) | HPGDHSD17B10SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL11394904 | 0.69 | ALDH1A1 (0.50) | HPGDHSD17B10NPSR1POLBSMN1; SMN2 | |
| SCHEMBL3248315 | 0.68 | DYRK1A (0.43) | HPGDHSD17B10NPSR1SMN1; SMN2GAA | |
| SCHEMBL3655311 | 0.64 | TSHR (0.48) | HSD17B10SMN1; SMN2GAAKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107922371-B | N-substituted hydroxamic acids with carbon-based leaving groups as efficient HNO donors and uses thereof | 约翰斯霍普金斯大学 | 2022-04-19 | — | — | CN | disclosed |
| EP-3313831-B1 | N-SUBSTITUTED HYDROXAMIC ACIDS WITH CARBON-BASED LEAVING GROUPS AS EFFICIENT HNO DONORS AND USES THEREOF | UNIV JOHNS HOPKINS (US) | 2021-03-10 | — | — | EP | disclosed |
| US-10583141-B2 | N-substituted hydroxamic acids with carbon-based leaving groups as efficient HNO donors and uses thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2020-03-10 | — | — | US | disclosed |
| US-20180185367-A1 | N-SUBSTITUTED HYDROXAMIC ACIDS WITH CARBON-BASED LEAVING GROUPS AS EFFICIENT HNO DONORS AND USES THEREOF | NATIONAL SCIENCE FOUNDATION | 2018-07-05 | — | — | US | disclosed |
| EP-3313831-A1 | N-SUBSTITUTED HYDROXAMIC ACIDS WITH CARBON-BASED LEAVING GROUPS AS EFFICIENT HNO DONORS AND USES THEREOF | The Johns Hopkins University (US) | 2018-05-02 | — | — | EP | disclosed |
| CN-107922371-A | Hydroxamic acid of the substitutions of the N with carbon-based leaving group as effective HNO donors and application thereof | 约翰斯霍普金斯大学 | 2018-04-17 | — | — | CN | disclosed |
| WO-2016210392-A1 | N-SUBSTITUTED HYDROXAMIC ACIDS WITH CARBON-BASED LEAVING GROUPS AS EFFICIENT HNO DONORS AND USES THEREOF | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-12-29 | — | — | WO | disclosed |
| EP-1716236-A2 | ANTISENSE OLIGONUCLEOTIDES FOR TREATING UNWANTED PIGMENTATION OF THE SKIN AND HAIR | Beiersdorf Aktiengesellschaft (DE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005078090-A2 | ANTISENSE OLIGONUCLEOTIDES FOR TREATING UNWANTED PIGMENTATION OF THE SKIN AND HAIR | BEIERSDORF AG (DE) | 2005-08-25 | — | — | WO | disclosed |
| EP-0591105-B1 | Bisazo, bisazomethine and azo-azomethine compounds | CIBA SC HOLDING AG (CH) | 2001-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180185367-A1 | N-SUBSTITUTED HYDROXAMIC ACIDS WITH CARBON-BASED LEAVING GROUPS AS EFFICIENT HNO DONORS AND USES THEREOF | HAAO, HAO2, HNMT | HPGD 9/4885HSD17B10 177/4885NPSR1 1230/4885 |
| US-10583141-B2 | N-substituted hydroxamic acids with carbon-based leaving groups as efficient HNO donors and uses thereof | HAAO, HAO2, HNMT | HPGD 9/4885HSD17B10 177/4885NPSR1 1230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.