Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | C1R | P00736 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4265253 | 0.78 | ELANE (0.60) | ELANEALDH1A1 | |
| SCHEMBL5963788 | 0.74 | RAB9A (0.61) | ELANERAB9ANPC1ALDH1A1GAA | |
| SCHEMBL6498064 | 0.67 | ELANE (1.00) | ELANEC1R | |
| SCHEMBL13158929 | 0.66 | RAB9A (1.00) | ELANERAB9ANPC1KMT2AALDH1A1 | |
| SCHEMBL13891488 | 0.66 | ELANE (0.42) | ELANERAB9ANPC1KMT2AALDH1A1 | |
| SCHEMBL4261407 | 0.65 | ALDH1A1 (0.61) | ELANENPC1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL8705044 | 0.65 | ELANE (0.36) | ELANERAB9ANPC1MAPT | |
| SCHEMBL6849716 | 0.64 | NPC1 (0.45) | ELANERAB9ANPC1KMT2AALDH1A1 | |
| SCHEMBL13891444 | 0.64 | ELANE (0.44) | ELANERAB9ANPC1KMT2AALDH1A1 | |
| SCHEMBL4395399 | 0.64 | TP53 (0.45) | ELANEALDH1A1SMN1; SMN2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1446125-A1 | THIENO-(1,3)-OXAZIN-4-ONES WITH LIPASE INHIBITING ACTIVITY | Alizyme Therapeutics Limited (GB) | 2004-08-18 | — | — | EP | claimed |
| WO-2003020282-A1 | THIENO-(1,3)-OXAZIN-4-ONES WITH LIPASE INHIBITING ACTIVITY | ALIZYME THERAPEUTICS LIMITED (GB) | 2003-03-13 | — | — | WO | claimed |