Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 11/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.76 |
| ▸ | CYP4Z1 | Q86W10 | 5/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | CYP4F11 | Q9HBI6 | 2/20 | 0.55 |
| ▸ | CYP4F12 | Q9HCS2 | 2/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | BID | P55957 | 2/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.33 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10982682 | 0.73 | LIPG (0.45) | CYP2C9CYP2D6CYP3A4LIPGALOX5 | |
| SCHEMBL3920104 | 0.71 | CYP3A4 (0.59) | CYP2C9CYP2D6CYP3A4LIPGALOX5 | |
| SCHEMBL822159 | 0.69 | TYR (0.53) | ALOX5PTGS2BIDBCL2L1MCL1 | |
| SCHEMBL2524117 | 0.68 | CYP3A4 (0.41) | CYP2C9CYP2D6CYP3A4LIPGALOX5 | |
| SCHEMBL630180 | 0.68 | LIPG (0.41) | CYP2C9CYP2D6CYP3A4LIPGALOX5 | |
| SCHEMBL21765629 | 0.67 | CYP3A4 (0.68) | CYP2C9CYP2D6CYP3A4LIPGALOX5 | |
| SCHEMBL11858843 | 0.67 | CYP3A4 (0.50) | CYP2C9CYP2D6CYP3A4CYP4Z1CYP1A2 | |
| SCHEMBL19487090 | 0.66 | CYP3A4 (0.38) | CYP2C9CYP2D6CYP3A4LIPGALOX5 | |
| SCHEMBL8095512 | 0.66 | BID (0.42) | CYP2C9CYP2D6CYP3A4LIPGALOX5 | |
| SCHEMBL819273 | 0.65 | LIPG (0.45) | CYP2C9CYP2D6CYP3A4LIPGALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682153-A2 | METHODS OF MODULATING ANGIOGENESIS AND CANCER CELL PROLIFERATION | MCW Research Foundation, Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| US-20050124618-A1 | Methods of modulating angiogenesis and cancer cell proliferation | HENRY FORD HEALTH SYSTEM | 2005-06-09 | — | — | US | disclosed |
| WO-2005046658-A2 | METHODS OF MODULATING ANGIOGENESIS AND CANCER CELL PROLIFERATION | MCW RESEARCH FOUNDATION, INC. (US) | 2005-05-26 | — | — | WO | disclosed |