⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL21821603 | 0.97 | LMNA (0.46) | — | |
| SCHEMBL13225487 | 0.89 | LMNA (0.43) | — | |
| SCHEMBL8404885 | 0.88 | LMNA (0.39) | — | |
| Acetic Acid SCHEMBL27521436 | 0.88 | FFAR3 (0.47) | — | |
| Acetic Acid SCHEMBL30401693 | 0.88 | CTH (0.48) | — | |
| Acetic Acid SCHEMBL31437203 | 0.88 | CTH (0.48) | — | |
| SCHEMBL690784 | 0.87 | — | — | |
| SCHEMBL22821625 | 0.87 | LMNA (0.42) | — | |
| Oxalic Acid SCHEMBL1401228 | 0.85 | ALDH1A1 (0.37) | — | |
| SCHEMBL27722358 | 0.84 | ALDH1A1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 247 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180338936-A1 | Methods and Compositions for the Treatment and Prevention of Allergic Rhinitis | MARTIN ALAIN (US) | 2018-11-29 | — | — | US | claimed |
| US-9675569-B2 | Method for treating a pulmonary disease state in mammals by up regulating indigenous in vivo levels of inflammatory agents in mammalian cells | CELLULAR SCIENCES, INC. | 2017-06-13 | — | — | US | claimed |
| US-20160022616-A1 | Method for Treating a Pulmonary Disease State in Mammals by Up Regulating Indigenous in vivo Levels of Inflammatory Agents in Mammalian Cells | CELLULAR SCIENCES, INC. | 2016-01-28 | — | — | US | claimed |
| WO-2013187891-A1 | METHOD FOR TREATING A PULMONARY DISEASE STATE IN MAMMALS BY UP REGULATING INDIGENOUS IN VIVO LEVELS OF INFLAMMATORY AGENTS IN MAMMALIAN CELLS | MARTIN ALAIN (US) | 2013-12-19 | — | — | WO | claimed |
| US-8211943-B2 | Method for treating a pulmonary disease state in mammals by up regulating indigenous in vivo levels of inflammatory agents in mammalian cells | CELLULAR SCIENCES, INC. | 2012-07-03 | — | — | US | claimed |
| US-8114907-B2 | Method for treating a pulmonary disease state in mammals by up regulating indigenous in vivo levels of inflammatory agents in mammalian cells | CELLULAR SCIENCES INC (US) | 2012-02-14 | — | — | US | claimed |
| EP-1183022-B1 | METHOD AND COMPOSITION FOR TREATING MAMMALIAN NASAL AND SINUS DISEASES CAUSED BY INFLAMMATORY RESPONSE | CELLULAR SCIENCES INC (US) | 2010-12-29 | — | — | EP | claimed |
| EP-2187738-A1 | METHOD FOR TREATING A PULMONARY DISEASE STATE IN MAMMALS BY UP OR DOWN REGULATING INDIGENOUS IN VIVO LEVELS OF INFLAMMATORY AGENTS IN MAMMALIAN CELLS | Cellular Sciences, Inc. (US) | 2010-05-26 | — | — | EP | claimed |
| US-20090041739-A1 | Method for treating a pulmonary disease state in mammals by up or down regulating indigenous in vivo levels of inflammatory agents in mammalian cells | CELLULAR SCIENCES, INC. | 2009-02-12 | — | — | US | claimed |
| US-20090041738-A1 | Method for treating a pulmonary disease state in mammals by up or down regulating indigenous in vivo levels of inflammatory agents in mammalian cells | CELLULAR SCIENCES, INC. | 2009-02-12 | — | — | US | claimed |
| US-5716926-A | ENHANCING THE PHYSICAL ENDURANCE OF MAMMAL BY ADMINISTERING TO MAMMAL THE ANABOLIC PROTEIN AND PYRUVATE | Beale, Paxton K. (US) | 1998-02-10 | — | — | US | claimed |
| WO-1998004254-A1 | COMPOSITION OF PYRUVATE AND PROTEIN AND METHOD FOR INCREASING PROTEIN CONCENTRATION IN A MAMMAL | BEALE PAXTON K (US) | 1998-02-05 | — | — | WO | claimed |
| WO-1998004253-A1 | COMPOSITION OF PYRUVATE AND ANTI-CORTISOL COMPOUNDS AND METHOD FOR INCREASING PROTEIN CONCENTRATION IN A MAMMAL | BEALE PAXTON K (US) | 1998-02-05 | — | — | WO | claimed |
| US-5508308-A | INJECTION INTO CORONARY ARTERY | ABBOTT LABORATORIES (US) | 1996-04-16 | — | — | US | claimed |
| US-5472980-A | Reducing insulin resistance in mammals with amino acid derivatives | ABBOTT LABORATORIES (US) | 1995-12-05 | — | — | US | claimed |
| EP-0636117-A4 | METHOD OF ADMINISTERING PYRUVATE AND METHODS OF SYNTHESIZING PYRUVATE PRECURSORS. | ABBOTT LAB (US) | 1995-07-26 | — | — | EP | claimed |
| EP-0636117-A1 | USE OF PYRUVAMIDE AND SELECTED PYRUVYL-AMINO ACIDS | ABBOTT LABORATORIES (US) | 1995-02-01 | — | — | EP | claimed |
| US-5283260-A | Oral ingesting a pyruvyl-amino acid compound before a glucose tolerance test | ABBOTT LABORATORIES (US) | 1994-02-01 | — | — | US | claimed |
| WO-1993021147-A1 | METHOD OF ADMINISTERING PYRUVATE AND METHODS OF SYNTHESIZING PYRUVATE PRECURSORS | ABBOTT LABORATORIES (US) | 1993-10-28 | — | — | WO | claimed |
| US-5256697-A | Covalently linked pyruvyl-amino compound | ABBOTT LABORATORIES | 1993-10-26 | — | — | US | claimed |