Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 15/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5971998 | 0.88 | MEN1 (0.46) | HTR6ADRB1HTR1AHTR7HTR2B | |
| SCHEMBL5972080 | 0.88 | HTR6 (0.52) | HTR6HTR7HTR2BTP53HTR2C | |
| SCHEMBL5202507 | 0.86 | HTR6 (0.52) | HTR6ADRB1HTR1AHTR7HTR2B | |
| SCHEMBL5972078 | 0.86 | ADRB1 (0.44) | HTR6ADRB1HTR1AHTR7HTR2B | |
| SCHEMBL5972087 | 0.82 | HTR6 (0.62) | HTR6AKT1PIK3CA | |
| SCHEMBL5201185 | 0.80 | HTR6 (0.49) | HTR6ADRB1HTR1AHTR7HTR2B | |
| SCHEMBL5971920 | 0.80 | HTR6 (0.59) | HTR6ADRB1AKT1PIK3CA | |
| SCHEMBL5201164 | 0.78 | HTR6 (0.62) | HTR6 | |
| Hydrochloric Acid SCHEMBL5205751 | 0.77 | HTR6 (0.63) | HTR6 | |
| SCHEMBL5202164 | 0.76 | ADRB1 (0.52) | HTR6ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556037-B1 | 4-PIPERAZINYL BENZENESULFONYL INDOLES WITH 5-HT6 RECEPTOR AFFINITY | HOFFMANN LA ROCHE (CH) | 2006-11-02 | — | — | EP | claimed |
| EP-1556037-A1 | 4-PIPERAZINYL BENZENESULFONYL INDOLES WITH 5-HT6 RECEPTOR AFFINITY | F. HOFFMANN-LA ROCHE AG (CH) | 2005-07-27 | — | — | EP | claimed |
| WO-2004035047-A1 | 4-PIPERAZINYL BENZENESULFONYL INDOLES WITH 5-HT6 RECEPTOR AFFINITY | F. HOFFMANN-LA ROCHE AG (CH) | 2004-04-29 | — | — | WO | claimed |
| EP-1556037-B1 | 4-PIPERAZINYL BENZENESULFONYL INDOLES WITH 5-HT6 RECEPTOR AFFINITY | HOFFMANN LA ROCHE (CH) | 2006-11-02 | — | — | EP | disclosed |
| US-7022708-B2 | 4-piperazinyl benzenesulfonyl indoles and uses thereof | ROCHE PALO ALTO LLC (US) | 2006-04-04 | — | — | US | disclosed |
| EP-1556037-A1 | 4-PIPERAZINYL BENZENESULFONYL INDOLES WITH 5-HT6 RECEPTOR AFFINITY | F. HOFFMANN-LA ROCHE AG (CH) | 2005-07-27 | — | — | EP | disclosed |
| US-20040087593-A1 | 4-Piperazinyl benzenesulfonyl indoles and uses thereof | ROCHE PALO ALTO LLC | 2004-05-06 | — | — | US | disclosed |
| WO-2004035047-A1 | 4-PIPERAZINYL BENZENESULFONYL INDOLES WITH 5-HT6 RECEPTOR AFFINITY | F. HOFFMANN-LA ROCHE AG (CH) | 2004-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040087593-A1 | 4-Piperazinyl benzenesulfonyl indoles and uses thereof | HTR6, HTR4, HTR5A | HTR6 1/4885ADRB1 40/4885JAK2 358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.