Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pargyline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB known ✓ | P27338 | 3/20 | 0.75 |
| ▸ | MAOA known ✓ | P21397 | 2/20 | 0.75 |
| ▸ | PYCR1 | P32322 | 17/20 | 0.75 |
| ▸ | LMNA | P02545 | 2/20 | 0.75 |
| ▸ | USP2 | O75604 | 1/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.75 |
| ▸ | TSHR | P16473 | 1/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.73 |
| ▸ | BLM | P54132 | 1/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pargyline SCHEMBL2657939 | 0.87 | PYCR1 (0.86) | PYCR1MAOBLMNAMAOAUSP2 | |
| Pargyline SCHEMBL2045 | 0.87 | PYCR1 (1.00) | PYCR1MAOBLMNAMAOAUSP2 | |
| Pargyline SCHEMBL18036659 | 0.87 | PYCR1 (1.00) | PYCR1MAOBLMNAMAOAUSP2 | |
| Pargyline SCHEMBL121111 | 0.85 | LMNA (1.00) | PYCR1MAOBLMNAMAOAUSP2 | |
| Pargyline SCHEMBL7363311 | 0.85 | PYCR1 (0.96) | PYCR1MAOBLMNAMAOAUSP2 | |
| Pargyline SCHEMBL4441967 | 0.84 | PYCR1 (0.75) | PYCR1MAOBLMNAMAOAUSP2 | |
| SCHEMBL10033801 | 0.78 | PYCR1 (0.79) | PYCR1MAOBLMNAMAOAUSP2 | |
| Metyrosine SCHEMBL28832620 | 0.76 | BLM (0.60) | PYCR1MAOBLMNAMAOAUSP2 | |
| SCHEMBL14125440 | 0.75 | PYCR1 (0.61) | PYCR1MAOBLMNAMAOAUSP2 | |
| SCHEMBL27391448 | 0.74 | PYCR1 (0.72) | PYCR1MAOBLMNAMAOAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7122198-B1 | Fast dissolving composition with prolonged sweet taste | PANACEA BIOTEC LIMITED (IN) | 2006-10-17 | — | — | US | disclosed |
| EP-1235561-A2 | FAST DISSOLVING COMPOSITION WITH PROLONGED SWEET TASTE | Panacea Biotec Limited (IN) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001039749-A2 | FAST DISSOLVING COMPOSITION WITH PROLONGED SWEET TASTE | PANACEA BIOTEC LIMITED (IN) | 2001-06-07 | — | — | WO | disclosed |