Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pargyline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB known ✓ | P27338 | 2/20 | 0.86 |
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.86 |
| ▸ | PYCR1 | P32322 | 17/20 | 0.86 |
| ▸ | LMNA | P02545 | 2/20 | 0.86 |
| ▸ | USP2 | O75604 | 1/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.86 |
| ▸ | TSHR | P16473 | 1/20 | 0.86 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.83 |
| ▸ | BLM | P54132 | 1/20 | 0.83 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.83 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.55 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.55 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pargyline SCHEMBL18036659 | 0.93 | PYCR1 (1.00) | PYCR1LMNAMAOBUSP2CYP3A4 | |
| Pargyline SCHEMBL2045 | 0.93 | PYCR1 (1.00) | PYCR1LMNAMAOBUSP2CYP3A4 | |
| Pargyline SCHEMBL121111 | 0.91 | LMNA (1.00) | PYCR1LMNAMAOBUSP2CYP3A4 | |
| Pargyline SCHEMBL7363311 | 0.91 | PYCR1 (0.96) | PYCR1LMNAMAOBUSP2CYP3A4 | |
| Pargyline SCHEMBL5981667 | 0.87 | PYCR1 (0.75) | PYCR1LMNAMAOBUSP2CYP3A4 | |
| Pargyline SCHEMBL4441967 | 0.80 | PYCR1 (0.75) | PYCR1LMNAMAOBUSP2CYP3A4 | |
| SCHEMBL11896612 | 0.78 | PYCR1 (0.72) | PYCR1LMNAMAOBUSP2CYP3A4 | |
| SCHEMBL5680713 | 0.78 | PYCR1 (0.70) | PYCR1LMNAMAOBUSP2CYP3A4 | |
| SCHEMBL10033796 | 0.78 | PYCR1 (0.71) | PYCR1LMNAMAOBUSP2CYP3A4 | |
| Pargyline SCHEMBL1240794 | 0.78 | PYCR1 (0.65) | PYCR1LMNAMAOBUSP2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994848-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2000-04-26 | — | — | EP | disclosed |
| WO-1999001423-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 1999-01-14 | — | — | WO | disclosed |