Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 17/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14350115 | 0.84 | HTT (0.56) | RAPGEF4HTTALDH1A1 | |
| SCHEMBL19194234 | 0.82 | POLB (0.46) | RAPGEF4ALDH1A1 | |
| SCHEMBL13911907 | 0.78 | METAP2 (0.53) | RAPGEF4HTTALDH1A1 | |
| SCHEMBL13034024 | 0.75 | RAPGEF4 (0.36) | RAPGEF4HTTALDH1A1 | |
| SCHEMBL25544886 | 0.75 | RAPGEF4 (0.44) | RAPGEF4HTTALDH1A1 | |
| SCHEMBL2927138 | 0.74 | ATM (0.43) | RAPGEF4ALDH1A1 | |
| SCHEMBL502929 | 0.71 | RAPGEF4 (1.00) | RAPGEF4 | |
| SCHEMBL16564657 | 0.70 | RAPGEF4 (0.37) | RAPGEF4HTTALDH1A1 | |
| SCHEMBL6575628 | 0.70 | RAPGEF4 (0.42) | RAPGEF4HTTALDH1A1 | |
| SCHEMBL246412 | 0.69 | RAPGEF4 (0.63) | RAPGEF4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656355-A2 | PIPERAZINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2006-05-17 | — | — | EP | disclosed |
| WO-2005061467-A2 | PIPERAZINE DERIVATIVES AS BRADYKININ ANTAGONISTS | AMGEN INC. (US) | 2005-07-07 | — | — | WO | disclosed |