Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29030467 | 0.97 | RAPGEF4 (0.41) | RAPGEF4NPSR1HTTMAPTGAA | |
| SCHEMBL16564657 | 0.94 | RAPGEF4 (0.37) | RAPGEF4NPSR1HTTMAPTGAA | |
| SCHEMBL16564651 | 0.84 | POLB (0.37) | RAPGEF4ALDH1A1TSHRCA2POLB | |
| SCHEMBL12764927 | 0.84 | RAPGEF4 (0.44) | RAPGEF4GAAALDH1A1LMNANPC1 | |
| SCHEMBL12135857 | 0.84 | RAPGEF4 (0.44) | RAPGEF4NPSR1GAAALDH1A1THRB | |
| SCHEMBL12203150 | 0.82 | SMN1; SMN2 (0.32) | MAPTLMNASMN1; SMN2 | |
| SCHEMBL17036634 | 0.80 | RAPGEF4 (0.50) | RAPGEF4MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8248072 | 0.75 | MAPT (0.54) | NPSR1HTTMAPTGAAALDH1A1 | |
| SCHEMBL21571870 | 0.74 | SLC22A12 (0.42) | MAPTNPC1 | |
| SCHEMBL5983235 | 0.72 | NPC1 (0.48) | RAPGEF4NPSR1HTTMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12018121-B2 | (Poly)alkylene glycol-containing compound | NIPPON SHOKUBAI CO., LTD. (JP) | 2024-06-25 | — | — | US | disclosed |
| US-20220073678-A1 | (POLY)ALKYLENE GLYCOL-CONTAINING COMPOUND | NIPPON SHOKUBAI CO., LTD. (JP) | 2022-03-10 | — | — | US | disclosed |
| EP-3892666-A1 | (POLY)ALKYLENE GLYCOL-CONTAINING COMPOUND | Nippon Shokubai Co., Ltd. (JP) | 2021-10-13 | — | — | EP | disclosed |
| WO-2020116549-A1 | (POLY)ALKYLENE GLYCOL-CONTAINING COMPOUND | 株式会社日本触媒 | 2020-06-11 | — | — | WO | disclosed |
| WO-2020116550-A1 | (POLY)ALKYLENE GLYCOL-CONTAINING COMPOUND | 株式会社日本触媒 | 2020-06-11 | — | — | WO | disclosed |
| US-10479793-B2 | Imidazopyridazine compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-11-19 | — | — | US | disclosed |
| US-10035790-B2 | RORγ modulators | EXELIXIS, INC. (US) | 2018-07-31 | — | — | US | disclosed |
| EP-2940000-B1 | PROCESS FOR PREPARING METHYL ACETATE | DALIAN INST CHEMICAL PHYSICS CAS (CN) | 2017-10-18 | — | — | EP | disclosed |
| US-9440226-B2 | Method for preparing methyl acetate | DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCES (CN) | 2016-09-13 | — | — | US | disclosed |
| US-20160096819-A1 | PROCESS FOR PREPARING N-SUBSTITUTED 1H-PYRAZOLE-5-CARBOXYLIC ACID COMPOUNDS AND DERIVATIVES THEREOF | BASF SE (DE) | 2016-04-07 | — | — | US | disclosed |
| US-20090048244-A1 | PYRROLOTRIAZINE COMPOUNDS AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2009-02-19 | — | — | US | disclosed |
| US-7297695-B2 | Pyrrolotriazine compounds as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-11-20 | — | — | US | disclosed |
| EP-1080084-B1 | PROCESS FOR EPOXIDATION OF ARYL ALLYL ETHERS | DOW GLOBAL TECHNOLOGIES INC (US) | 2004-05-06 | — | — | EP | disclosed |
| US-6462213-B1 | A THREE COORDINATE, LOW OXIDATION STATE TRANSITION METAL COMPLEX CAPABLE OF GEREATING AMMONIA FROM DINITROGEN UNDER SUBSTANTIALLY ATMOSPHERIC PRESSURES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2002-10-08 | — | — | US | disclosed |
| CN-1303382-A | Epoxidation process for aryl allyl ethers | DOW CHEMICAL CO (US) | 2001-07-11 | — | — | CN | disclosed |
| EP-1080084-A2 | PROCESS FOR EPOXIDATION OF ARYL ALLYL ETHERS | THE DOW CHEMICAL COMPANY (US) | 2001-03-07 | — | — | EP | disclosed |
| US-6117407-A | Method for the generation of ammonia | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2000-09-12 | — | — | US | disclosed |
| US-6087513-A | REACTION OF ALLYL ARYL ETHER WITH HYDROGEN PEROXIDE IN THE PRESENCE OF TRANSITION METALS FOR OXIDATION | THE DOW CHEMICAL COMPANY (US) | 2000-07-11 | — | — | US | disclosed |
| US-6037459-A | Dinitrogen cleavage | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2000-03-14 | — | — | US | disclosed |
| WO-1999062894-A2 | PROCESS FOR EPOXIDATION OF ARYL ALLYL ETHERS | THE DOW CHEMICAL COMPANY (US) | 1999-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10035790-B2 | RORγ modulators | RORB, RORA, RORC | RAPGEF4 1512/4885NPSR1 88/4885HTT 4137/4885 |
| US-10479793-B2 | Imidazopyridazine compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses | TYK2, IL2, JAK3 | RAPGEF4 3690/4885NPSR1 3655/4885HTT 4170/4885 |
| US-20090048244-A1 | PYRROLOTRIAZINE COMPOUNDS AS KINASE INHIBITORS | ERBB2, ERBB4, ERBB3 | RAPGEF4 677/4885NPSR1 764/4885HTT 1673/4885 |
| US-20160096819-A1 | PROCESS FOR PREPARING N-SUBSTITUTED 1H-PYRAZOLE-5-CARBOXYLIC ACID COMPOUNDS AND DERIVATIVES THEREOF | CA3, CA2, CA1 | RAPGEF4 1530/4885NPSR1 2848/4885HTT 4172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.