Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.41 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.41 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9768655 | 0.84 | FOLH1 (0.47) | SMN1; SMN2HSD17B10RAB9ANPC1 | |
| SCHEMBL7459760 | 0.84 | HNF4A (0.47) | SMN1; SMN2MCL1AKR1C2AKR1C1HSD17B10 | |
| SCHEMBL2553639 | 0.75 | ALDH1A1 (0.42) | SMN1; SMN2MCL1HSD17B10ALDH1A1GAA | |
| SCHEMBL31402608 | 0.74 | KMT2A (0.60) | SMN1; SMN2MCL1ALDH1A1AKR1C3GAA | |
| SCHEMBL6495696 | 0.74 | HSD17B10 (0.58) | SMN1; SMN2MCL1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL372 | 0.74 | KMT2A (0.60) | SMN1; SMN2MCL1ALDH1A1AKR1C3GAA | |
| SCHEMBL9988102 | 0.74 | BACE1 (0.38) | MCL1HSD17B10ALDH1A1RAB9ANPC1 | |
| SCHEMBL30832923 | 0.74 | MCL1 (0.58) | SMN1; SMN2MCL1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL3544339 | 0.74 | ACHE (0.35) | ALDH1A1RAB9ANPC1KMT2A | |
| Hydrochloric Acid SCHEMBL7610390 | 0.73 | KMT2A (0.59) | SMN1; SMN2MCL1ALDH1A1AKR1C3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656355-A2 | PIPERAZINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2006-05-17 | — | — | EP | disclosed |
| WO-2005061467-A2 | PIPERAZINE DERIVATIVES AS BRADYKININ ANTAGONISTS | AMGEN INC. (US) | 2005-07-07 | — | — | WO | disclosed |