Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 6/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 3/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4806229 | 0.94 | NPSR1 (0.44) | NPSR1MAPK1MITFLMNACNR1 | |
| SCHEMBL4806912 | 0.92 | CACNA1G (0.40) | NPSR1MAPK1MITFLMNACNR1 | |
| SCHEMBL14080796 | 0.74 | LPAR1 (0.41) | ARFNTAFNTBPGGT1BSLC6A4 | |
| SCHEMBL14080782 | 0.71 | KCNJ1 (0.40) | SLC22A12LTA4HARTRPV4 | |
| SCHEMBL3699384 | 0.70 | OPRM1 (0.45) | NPSR1MAPK1MITFLMNACNR1 | |
| SCHEMBL8549611 | 0.68 | CYP19A1 (0.49) | ARCACNA1GCACNA1BFNTAFNTB | |
| SCHEMBL10535321 | 0.68 | TRPV4 (0.55) | SLC22A12ARTRPV4 | |
| SCHEMBL28748012 | 0.68 | TRPV4 (0.46) | SLC22A12ARTRPV4 | |
| SCHEMBL14106705 | 0.67 | LPAR1 (0.47) | AR | |
| SCHEMBL3694628 | 0.67 | OPRK1 (0.49) | NPSR1MAPK1MAPTKCNH2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699783-A1 | OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005066164-A1 | OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-07-21 | — | — | WO | disclosed |