Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 15/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5984831 | 0.83 | STS (0.56) | ALDH1A1 | |
| SCHEMBL4492750 | 0.80 | ENPP2 (0.45) | ENPP2 | |
| SCHEMBL16053741 | 0.76 | ENPP2 (0.46) | ENPP2KIT | |
| SCHEMBL1433531 | 0.75 | NOS2 (0.44) | KITNOS1NOS2KDM4EALDH1A1 | |
| SCHEMBL5968192 | 0.75 | JAK2 (0.42) | ENPP2KITALDH1A1SMN1; SMN2KCNH2 | |
| SCHEMBL5993383 | 0.74 | MAPT (0.51) | KDM4EALDH1A1SMN1; SMN2KCNH2 | |
| SCHEMBL5030313 | 0.72 | GAA (0.48) | KITKDM4ESMN1; SMN2 | |
| SCHEMBL5308786 | 0.72 | THRB (0.62) | HSD11B1KITNOS1NOS2SMN1; SMN2 | |
| SCHEMBL5968252 | 0.71 | KDM4E (0.46) | HSD11B1KITKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL651891 | 0.71 | HTT (0.53) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660064-A2 | TREATMENT OF LEARNING DISABILITIES AND MOTOR SKILLS DISORDER WITH NOREPINEPHRINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005020975-A2 | TREATMENT OF LEARNING DISABILITIES AND MOTOR SKILLS DISORDER WITH NOREPINEPHRINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-03-10 | — | — | WO | disclosed |