Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5990314 | 0.91 | DNM1 (0.35) | DNM1HTTSMN1; SMN2RAB9ALMNA | |
| SCHEMBL10756971 | 0.89 | DNM1 (0.37) | DNM1HTTSMN1; SMN2RAB9ALMNA | |
| SCHEMBL14039826 | 0.87 | HTT (0.46) | DNM1HTTSMN1; SMN2RAB9ALMNA | |
| Bromide SCHEMBL4169087 | 0.84 | HTT (0.50) | DNM1HTTSMN1; SMN2RAB9ALMNA | |
| Hydrochloric Acid SCHEMBL5990146 | 0.82 | CYP3A4 (0.43) | DNM1LMNAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4612119 | 0.82 | HTT (0.37) | DNM1HTTSMN1; SMN2RAB9ALMNA | |
| Hydrochloric Acid SCHEMBL4660185 | 0.81 | HTT (0.59) | DNM1HTTSMN1; SMN2RAB9ALMNA | |
| SCHEMBL19762859 | 0.80 | — | — | |
| Bromide SCHEMBL4170067 | 0.80 | HTT (0.40) | DNM1HTTSMN1; SMN2RAB9ALMNA | |
| SCHEMBL3891425 | 0.78 | HTT (0.61) | DNM1HTTSMN1; SMN2RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7030075-B2 | Organic activator | PROCTER & GAMBLE COMPANY (US) | 2006-04-18 | — | — | US | disclosed |
| US-20060074001-A1 | Organic activator | MIRACLE GREOGORY S | 2006-04-06 | — | — | US | disclosed |
| EP-1572631-A2 | ORGANIC ACTIVATOR | The Procter & Gamble Company (US) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004060856-A2 | ORGANIC ACTIVATOR | THE PROCTER & GAMBLE COMPANY (US) | 2004-07-22 | — | — | WO | disclosed |
| US-20040142844-A1 | bleach activators; N-hydroxyalkyl quaternary ammonium acetonitriles, e.g., 1-cyano-N,N-dimethyl-N-(3-hydroxypropyl)methanaminium chloride or quaternary ammonium acetonitrile inner salts, e.g., 5-carboxy-N,N-dimethyl-N-(cyanomethyl)-1-pentanaminium | THE PROCTER & GAMBLE COMPANY | 2004-07-22 | — | — | US | disclosed |