Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.33 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.32 |
| ▸ | RAD52 | P43351 | 2/20 | 0.32 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.30 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4612119 | 0.97 | HTT (0.37) | HTTSMN1; SMN2RAB9ALMNAMEN1 | |
| Bromide SCHEMBL4169087 | 0.90 | HTT (0.50) | HTTSMN1; SMN2RAB9ALMNAMEN1 | |
| SCHEMBL14039826 | 0.86 | HTT (0.46) | HTTSMN1; SMN2RAB9ALMNAMEN1 | |
| Hydrochloric Acid SCHEMBL4611856 | 0.86 | ALDH1A1 (0.32) | HTTSMN1; SMN2RAB9ALMNAMEN1 | |
| Hydrochloric Acid SCHEMBL5990314 | 0.83 | DNM1 (0.35) | HTTSMN1; SMN2RAB9ALMNAMEN1 | |
| SCHEMBL4253271 | 0.83 | ALDH1A1 (0.33) | HTTSMN1; SMN2RAB9ALMNAMEN1 | |
| Hydrochloric Acid SCHEMBL4660185 | 0.81 | HTT (0.59) | HTTSMN1; SMN2RAB9ALMNAMEN1 | |
| SCHEMBL10756971 | 0.80 | DNM1 (0.37) | HTTSMN1; SMN2RAB9ALMNAMEN1 | |
| Hydrochloric Acid SCHEMBL5989564 | 0.80 | DNM1 (0.42) | HTTSMN1; SMN2RAB9ALMNAMEN1 | |
| SCHEMBL3891425 | 0.78 | HTT (0.61) | HTTSMN1; SMN2RAB9ALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023942-A1 | Method for Producing Bi-Functional Ammonium Nitriles | CLARIANT PRODUKTE (DEUTSCHALND) GMBH (DE) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023942-A1 | Method for Producing Bi-Functional Ammonium Nitriles | DBF4, AADAC, NAAA | HTT 2536/4885SMN1; SMN2 4470/4885RAB9A 4188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.