Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.60 |
| ▸ | HPGD | P15428 | 6/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.60 |
| ▸ | TP53 | P04637 | 5/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | USP2 | O75604 | 2/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.60 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4464671 | 0.88 | SMN1; SMN2 (0.74) | ALDH1A1SMN1; SMN2HPGDMAPTHSD17B10 | |
| SCHEMBL3611718 | 0.83 | THRB (0.50) | ALDH1A1SMN1; SMN2HPGDMAPTHSD17B10 | |
| SCHEMBL5989739 | 0.78 | MAPT (0.63) | ALDH1A1SMN1; SMN2HPGDMAPTHSD17B10 | |
| SCHEMBL678215 | 0.77 | SMN1; SMN2 (0.74) | ALDH1A1SMN1; SMN2HPGDMAPTHSD17B10 | |
| SCHEMBL30231625 | 0.77 | MAP1LC3B (0.74) | ALDH1A1SMN1; SMN2HPGDMAPTHSD17B10 | |
| SCHEMBL11547196 | 0.76 | THRB (0.46) | ALDH1A1SMN1; SMN2HPGDMAPTHSD17B10 | |
| 5,7-Dihydroxyisoflavone SCHEMBL1586459 | 0.75 | MEN1 (1.00) | ALDH1A1SMN1; SMN2HPGDMAPTHSD17B10 | |
| SCHEMBL12184598 | 0.74 | SIRT1 (0.79) | ALDH1A1SMN1; SMN2HPGDMAPTHSD17B10 | |
| SCHEMBL10623004 | 0.73 | SMN1; SMN2 (0.94) | ALDH1A1SMN1; SMN2HPGDMAPTHSD17B10 | |
| SCHEMBL6266319 | 0.72 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2HPGDMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060257987-A1 | Ppar modulators | ELI LILLY AND COMPANY | 2006-11-16 | — | — | US | disclosed |
| EP-1660428-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005019151-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-03-03 | — | — | WO | disclosed |