Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.47 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CBR1 | P16152 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5990371 | 0.85 | SCN8A (0.50) | SCN8ASCN10ASLC6A2SLC6A3LMNA | |
| SCHEMBL4504793 | 0.85 | KDM4E (0.47) | SLC6A2SLC6A3LMNANR1I2TTR | |
| SCHEMBL5989716 | 0.79 | HTR2C (0.48) | SCN8ASCN10ALMNAMAPTHPGD | |
| SCHEMBL10456772 | 0.78 | TRPA1 (0.56) | TRPA1HSPB1 | |
| SCHEMBL5990581 | 0.78 | SCN8A (0.49) | SCN8ASCN10ATRPA1 | |
| SCHEMBL19524125 | 0.77 | SCN8A (0.43) | SCN8ASCN10ASLC6A2SLC6A3LMNA | |
| SCHEMBL4135441 | 0.77 | TTR (0.75) | SLC6A2SLC6A3LMNANR1I2TTR | |
| SCHEMBL5991434 | 0.76 | SCN8A (0.45) | SCN8ASCN10ASLC6A2SLC6A3TTR | |
| SCHEMBL5363263 | 0.76 | SCN8A (0.57) | SCN8ASCN10ALMNAHPGDTAS1R3 | |
| SCHEMBL5991900 | 0.75 | PTGER4 (0.44) | SLC6A2SLC6A3LMNASLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060257987-A1 | Ppar modulators | ELI LILLY AND COMPANY | 2006-11-16 | — | — | US | disclosed |
| EP-1660428-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005019151-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-03-03 | — | — | WO | disclosed |