Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 15/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5991686 | 0.80 | CYP19A1 (0.52) | CYP19A1STS | |
| SCHEMBL8710073 | 0.78 | SLC6A4 (0.43) | CYP19A1KMT2ASLC9A1KEAP1 | |
| SCHEMBL4245748 | 0.77 | SLC9A1 (0.48) | CYP19A1KMT2ASLC9A1KEAP1 | |
| Hydrochloric Acid SCHEMBL8710121 | 0.77 | SLC6A4 (0.43) | CYP19A1KMT2ASLC9A1KEAP1 | |
| SCHEMBL8445461 | 0.76 | CYP19A1 (0.40) | CYP19A1 | |
| SCHEMBL5992333 | 0.73 | LOXL2 (0.54) | CYP19A1KMT2ASTSKCNJ1KCNH2 | |
| SCHEMBL5991160 | 0.70 | CYP2A6 (0.55) | CYP19A1KDM1A | |
| SCHEMBL282111 | 0.68 | SLC9A1 (0.48) | CYP19A1SLC9A1KEAP1 | |
| SCHEMBL22862868 | 0.68 | KEAP1 (0.48) | CYP19A1SLC9A1KEAP1 | |
| SCHEMBL19915948 | 0.68 | HCAR3 (0.50) | KMT2ASLC9A1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572665-B1 | 1-N-PHENYLAMINO-1H-IMIDAZOLE DERIVATIVES AS AROMATASE INHIBITORS | THERAMEX (MC) | 2006-05-03 | — | — | EP | disclosed |
| EP-1431292-A1 | 1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors | LABORATOIRE THERAMEX (MC) | 2004-06-23 | — | — | EP | disclosed |
| US-6737433-B1 | ESTROGEN DEPENDENT ANTITUMOR AGENTS | LABORATOIRE THERAMEX (MC) | 2004-05-18 | — | — | US | disclosed |