Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.32 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.32 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 6/20 | 0.32 |
| ▸ | RAB9A | P51151 | 6/20 | 0.32 |
| ▸ | HTT | P42858 | 5/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.31 |
| ▸ | GALR3 | O60755 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | ATM | Q13315 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11355995 | 0.96 | LTA4H (0.35) | LTA4HL3MBTL1GNAI3GNAO1GNAI1 | |
| SCHEMBL371279 | 0.94 | GNAI3 (0.33) | LTA4HGNAI3GNAO1GNAI1NPC1 | |
| SCHEMBL28042239 | 0.88 | CYP1A2 (0.30) | — | |
| SCHEMBL5174927 | 0.86 | GNAI3 (0.35) | GNAI3GNAO1GNAI1NPC1RAB9A | |
| SCHEMBL23912452 | 0.84 | GNAI3 (0.38) | GNAI3GNAO1GNAI1NPC1RAB9A | |
| SCHEMBL27451155 | 0.84 | GNAI3 (0.38) | GNAI3GNAO1GNAI1NPC1RAB9A | |
| Bromide SCHEMBL29130097 | 0.84 | NPC1 (0.36) | GNAI3GNAO1GNAI1NPC1RAB9A | |
| SCHEMBL27616893 | 0.84 | GNAI3 (0.34) | GNAI3GNAO1GNAI1NPC1RAB9A | |
| SCHEMBL28282304 | 0.84 | GNAI3 (0.38) | GNAI3GNAO1GNAI1NPC1RAB9A | |
| SCHEMBL27450698 | 0.84 | GNAI3 (0.38) | GNAI3GNAO1GNAI1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6992079-B2 | Substituted 11-phenyl-dibenzazepine compounds useful for the treatment or prevention of diseases characterized by abnormal cell proliferation | President Fellows of Harvard College (US) | 2006-01-31 | — | — | US | disclosed |
| US-20040002486-A1 | Substituted 11-phenyl-dibenzazepine compounds useful for the treatment or prevention of diseases characterized by abnormal cell proliferation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2004-01-01 | — | — | US | disclosed |
| US-20030191111-A1 | Substituted 11-phenyl-dibenzazepine compounds useful for the treatment or prevention of diseases characterized by abnormal cell proliferation | CHILDREN'S MEDICAL CENTER CORPORATION | 2003-10-09 | — | — | US | disclosed |
| US-20030134842-A1 | METHODS FOR THE TREATMENT OR PREVENTION OF INFLAMMATORY DISEASES CHARACTERIZED BY ABNORMAL CELL PROLIFERATION | BRUGNARA CARLO (US) | 2003-07-17 | — | — | US | disclosed |
| US-6534497-B1 | Specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by | NUCHEM PHARMACEUTICALS, INC. (CA) | 2003-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040002486-A1 | Substituted 11-phenyl-dibenzazepine compounds useful for the treatment or prevention of diseases characterized by abnormal cell proliferation | MKI67, BOD1L1, BRCA1 | LTA4H 3774/4885L3MBTL1 185/4885GNAI3 2774/4885 |
| US-20030191111-A1 | Substituted 11-phenyl-dibenzazepine compounds useful for the treatment or prevention of diseases characterized by abnormal cell proliferation | MKI67, BOD1L1, BRCA1 | LTA4H 3774/4885L3MBTL1 185/4885GNAI3 2774/4885 |
| US-20030134842-A1 | METHODS FOR THE TREATMENT OR PREVENTION OF INFLAMMATORY DISEASES CHARACTERIZED BY ABNORMAL CELL PROLIFERATION | KCNN2, KCNN1, KCNN3 | LTA4H 1166/4885L3MBTL1 3651/4885GNAI3 542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.