Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | ERN1 | O75460 | 2/20 | 0.43 |
| ▸ | IAPP | P10997 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.37 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MPI | P34949 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL29276804 | 0.98 | TRPA1 (0.46) | TRPA1ATMERN1IAPPMAPT | |
| SCHEMBL9618491 | 0.80 | ERN1 (0.61) | TRPA1ERN1IAPPMAPTLMNA | |
| SCHEMBL276965 | 0.79 | TRIM24 (0.52) | TRPA1ERN1MAPTLMNAPOLB | |
| SCHEMBL31000832 | 0.79 | TRIM24 (0.52) | TRPA1ERN1MAPTLMNAPOLB | |
| SCHEMBL7113862 | 0.78 | ERN1 (0.43) | TRPA1ATMERN1IAPPMAPT | |
| SCHEMBL16956018 | 0.77 | TRPA1 (0.52) | TRPA1ATMERN1IAPPMAPT | |
| SCHEMBL24832683 | 0.77 | ERN1 (0.44) | TRPA1ERN1GAAALDH1A1NPC1 | |
| SCHEMBL2359891 | 0.77 | ERN1 (0.42) | TRPA1ATMERN1IAPPMAPT | |
| SCHEMBL5440903 | 0.77 | ERN1 (0.44) | TRPA1ERN1IAPPMAPTLMNA | |
| SCHEMBL210332 | 0.76 | ERN1 (0.61) | TRPA1ATMERN1IAPPMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118344511-A | Mannich base and preparation method and application thereof | 中国石油化工股份有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-118344512-A | Mannich base and preparation method and application thereof | 中国石油化工股份有限公司 | 2024-07-16 | — | — | CN | disclosed |
| EP-2842935-B1 | MANNICH BASE, PREPARATION METHOD FOR SAME, AND APPLICATION THEREOF | CHINA PETROLEUM & CHEM CORP (CN) | 2019-06-12 | — | — | EP | disclosed |
| US-9938479-B2 | Use of amines and/or Mannich adducts in fuel and lubricant compositions for direct-injection spark ignition engines | BASF SE (DE) | 2018-04-10 | — | — | US | disclosed |
| US-9593290-B2 | Lubricating oil composition and production thereof | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2017-03-14 | — | — | US | disclosed |
| US-9587198-B2 | Mannich base, production and use thereof | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2017-03-07 | — | — | US | disclosed |
| US-20160222309-A1 | USE OF AMINES AND/OR MANNICH ADDUCTS IN FUEL AND LUBRICANT COMPOSITIONS FOR DIRECT-INJECTION SPARK IGNITION ENGINES | BASF SE (DE) | 2016-08-04 | — | — | US | disclosed |
| US-9309475-B2 | Use of amines and/or Mannich adducts in fuel and lubricant compositions for direct injection spark ignition engines | BASF SE (DE) | 2016-04-12 | — | — | US | disclosed |
| US-20150121747-A1 | MANNICH BASE, PRODUCTION AND USE THEREOF | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2015-05-07 | — | — | US | disclosed |
| US-20150126420-A1 | LUBRICATING OIL COMPOSITION AND PRODUCTION THEREOF | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2015-05-07 | — | — | US | disclosed |
| EP-2842935-A1 | MANNICH BASE, PREPARATION METHOD FOR SAME, AND APPLICATION THEREOF | China Petroleum & Chemical Corporation (CN) | 2015-03-04 | — | — | EP | disclosed |
| US-20130237466-A1 | USE OF AMINES AND/OR MANNICH ADDUCTS IN FUEL AND LUBRICANT COMPOSITIONS FOR DIRECT INJECTION SPARK IGNITION ENGINES | BASF SE (DE) | 2013-09-12 | — | — | US | disclosed |
| US-8449630-B2 | Use of amines and/or Mannich adducts in fuel and lubricant compositions for direct injection spark ignition engines | BASF SE (DE) | 2013-05-28 | — | — | US | disclosed |
| US-20060070293-A1 | Use of amines and/or mannich adducts in fuel and lubricant compositions for direct injection spark ignition engines | BASF SE (DE) | 2006-04-06 | — | — | US | disclosed |
| US-6914163-B2 | Method for producing polyisobutylphenols | BASF AG (DE) | 2005-07-05 | — | — | US | disclosed |
| US-6875897-B1 | Method for producing polyisobutenylphenols | BASF AKTIENGESELLSCHAFT (DE) | 2005-04-05 | — | — | US | disclosed |
| US-20030187171-A1 | Method for producing polyisobutylphenols | BASF AKTIENGESELLSCHAFT (DE) | 2003-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187171-A1 | Method for producing polyisobutylphenols | PCNA, PCBP1, PAH | TRPA1 3689/4885ATM 4210/4885ERN1 3373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.