SCHEMBL5993446

SCHEMBL5993446

C=C(C)C(=O)NCCCNC(=O)C(CS)NS(=O)(=O)c1cc(O)c2ccc3c(S(=O)(=O)NC(CS)C(=O)NCCCNC(=O)C(=C)C)cc(S(=O)(=O)NC(CS)C(=O)NCCCNC(=O)C(=C)C)c4ccc1c2c34

nearest known ligand 0.33

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PSMB8 P28062 4/20 0.32
PSMB5 P28074 3/20 0.32
LMNA P02545 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
NPY5R Q15761 1/20 0.30
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13039206 0.90 LMNA (0.32) PSMB8PSMB5LMNASMN1; SMN2NPY5R
SCHEMBL13039234 0.88 ALDH1A1 (0.32) PSMB8PSMB5LMNASMN1; SMN2
SCHEMBL13039204 0.88 LMNA (0.31) LMNASMN1; SMN2NPY5R
SCHEMBL13039221 0.87 ALDH1A1 (0.33) PSMB8PSMB5LMNASMN1; SMN2NPY5R
SCHEMBL9962935 0.82
SCHEMBL9962930 0.80
SCHEMBL13041270 0.80 BRD4 (0.33) NPY5R
SCHEMBL13039208 0.80 BRD4 (0.33) NPY5R
SCHEMBL10168476 0.78 ALDH1A1 (0.40) LMNASMN1; SMN2CA1CA2
SCHEMBL13039223 0.78 TDP1 (0.34) SMN1; SMN2NPY5R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120208286-A1 PYRIDINIUM BORONIC ACID QUENCHERS FOR USE IN ANALYTE SENSORS GLUMETRICS, INC. (US) 2012-08-16 US disclosed
US-8178676-B2 Pyridinium boronic acid quenchers for use in analyte sensors GLUMETRICS, INC. (US) 2012-05-15 US disclosed
US-20120116191-A1 USE OF AN EQUILIBRIUM INTRAVASCULAR SENSOR TO ACHIEVE TIGHT GLYCEMIC CONTROL GLUMETRICS, INC. (US) 2012-05-10 US disclosed
US-20120053427-A1 OPTICAL SENSOR CONFIGURATION AND METHODS FOR MONITORING GLUCOSE ACTIVITY IN INTERSTITIAL FLUID GLUMETRICS, INC. (US) 2012-03-01 US disclosed
US-20110263953-A1 DEPLOYMENT SYSTEM AND METHOD FOR OPTICAL ANALYTE SENSOR GLUMETRICS, INC. (US) 2011-10-27 US disclosed
US-20110224516-A1 MEASUREMENT DEVICES AND METHODS FOR MEASURING ANALYTE CONCENTRATION INCORPORATING TEMPERATURE AND PH CORRECTION GLUMETRICS, INC. (US) 2011-09-15 US disclosed
US-20110171742-A1 PYRIDINIUM BORONIC ACID QUENCHERS FOR USE IN ANALYTE SENSORS GLUMETRICS, INC. (US) 2011-07-14 US disclosed
US-20110105866-A1 OPTICAL SENSOR CONFIGURATION FOR RATIOMETRIC CORRECTION OF BLOOD GLUCOSE MEASUREMENT GLUMETRICS, INC. (US) 2011-05-05 US disclosed
US-20100274110-A1 OPTICAL DETERMINATION OF PH AND GLUCOSE GluMetrics, Inc (US) 2010-10-28 US disclosed
US-7767846-B2 Fluorescent dyes for use in glucose sensing GLUMETRICS, INC. (US) 2010-08-03 US disclosed
US-20090018418-A1 EQUILIBRIUM NON-CONSUMING FLUORESCENCE SENSOR FOR REAL TIME INTRAVASCULAR GLUCOSE MEASUREMENT GLUMETRICS, INC. (US) 2009-01-15 US disclosed
US-20080305506-A1 FLUORESCENT DYES FOR USE IN GLUCOSE SENSING GLUMETRICS INC. (US) 2008-12-11 US disclosed
US-20080305009-A1 PYRIDINIUM BORONIC ACID QUENCHERS FOR USE IN ANALYTE SENSORS GLUMETRICS INC. (US) 2008-12-11 US disclosed
US-7417164-B2 Fluorescent dyes for use in glucose sensing GLUMETRICS INC. (US) 2008-08-26 US disclosed
US-20080188725-A1 OPTICAL SYSTEMS AND METHODS FOR RATIOMETRIC MEASUREMENT OF BLOOD GLUCOSE CONCENTRATION MEDTRONIC MINIMED, INC. 2008-08-07 US disclosed
US-20080027245-A1 FLUORESCENT DYES FOR USE IN GLUCOSE SENSING GLUMETRICS INC. (US) 2008-01-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080027245-A1 FLUORESCENT DYES FOR USE IN GLUCOSE SENSING SLC2A4, SLC2A8, SLC2A1 PSMB8 4567/4885PSMB5 4545/4885LMNA 3715/4885
US-20120208286-A1 PYRIDINIUM BORONIC ACID QUENCHERS FOR USE IN ANALYTE SENSORS BLVRB, PDXK, PNPO PSMB8 4286/4885PSMB5 3846/4885LMNA 1686/4885
US-20080305009-A1 PYRIDINIUM BORONIC ACID QUENCHERS FOR USE IN ANALYTE SENSORS BLVRB, PDXK, PNPO PSMB8 4286/4885PSMB5 3846/4885LMNA 1686/4885
US-20110171742-A1 PYRIDINIUM BORONIC ACID QUENCHERS FOR USE IN ANALYTE SENSORS BLVRB, PDXK, PNPO PSMB8 4286/4885PSMB5 3846/4885LMNA 1686/4885
US-20080305506-A1 FLUORESCENT DYES FOR USE IN GLUCOSE SENSING SLC2A4, SLC2A8, SLC2A1 PSMB8 4567/4885PSMB5 4545/4885LMNA 3715/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.