Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.32 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.32 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.32 |
| ▸ | CDC25B | P30305 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.32 |
| ▸ | EDNRB | P24530 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL3440649 | 0.90 | MEN1 (0.33) | S100A4MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL9617399 | 0.76 | MEN1 (0.40) | S100A4MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL11411069 | 0.76 | POLB (0.40) | MEN1KMT2APOLBALDH1A1ALOX15 | |
| SCHEMBL4060635 | 0.76 | MEN1 (0.40) | S100A4MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL1032657 | 0.76 | KMT2A (0.40) | MEN1KMT2APOLBALDH1A1ALOX15 | |
| SCHEMBL16012917 | 0.76 | MEN1 (0.40) | S100A4MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL11052520 | 0.76 | POLB (0.40) | S100A4MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL6314591 | 0.76 | MEN1 (0.40) | MEN1KMT2APOLBALDH1A1ALOX15 | |
| SCHEMBL7892212 | 0.74 | ALDH1A1 (0.41) | MEN1KMT2APOLBALDH1A1KDM4E | |
| SCHEMBL10670754 | 0.73 | MEN1 (0.38) | MEN1KMT2APOLBALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4207112-A | STORAGE STABILITY | FUJI PHOTO FILM CO., LTD. (JP) | 1980-06-10 | — | — | US | claimed |
| US-10889576-B2 | Phthalazinone compounds and methods for the treatment of cystic fibrosis | FLATLEY DISCOVERY LAB, LLC (US) | 2021-01-12 | — | — | US | disclosed |
| US-20190256505-A1 | PHTHALAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | FLATLEY DISCOVERY LAB LLC (US) | 2019-08-22 | — | — | US | disclosed |
| US-10370366-B2 | Pyridazinone compounds and methods for the treatment of cystic fibrosis | FLATLEY DISCOVERY LAB, LLC (US) | 2019-08-06 | — | — | US | disclosed |
| US-10280160-B2 | Phthalazinone compounds and methods for the treatment of cystic fibrosis | FLATLEY DISCOVERY LAB, LLC (US) | 2019-05-07 | — | — | US | disclosed |
| CN-109384727-A | Phthalazines ketone compounds, preparation method, pharmaceutical composition and purposes | 中国科学院上海药物研究所 | 2019-02-26 | — | — | CN | disclosed |
| US-20180093976-A1 | PYRIDAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | FLATLEY DISCOVERY LAB LLC (US) | 2018-04-05 | — | — | US | disclosed |
| US-20180044330-A1 | PHTHALAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | FLATLEY DISCOVERY LAB LLC (US) | 2018-02-15 | — | — | US | disclosed |
| US-9783529-B2 | Pyridazinone compounds and methods for the treatment of cystic fibrosis | FLATLEY DISCOVERY LAB, LLC (US) | 2017-10-10 | — | — | US | disclosed |
| US-9682969-B2 | Phthalazinone compounds and methods for the treatment of cystic fibrosis | FLATLEY DISCOVERY LAB, LLC (US) | 2017-06-20 | — | — | US | disclosed |
| US-20120040983-A1 | Phthalazine Compounds as P38 Map Kinase Modulators and Methods of Use Thereof | AMGEN INC. (US) | 2012-02-16 | — | — | US | disclosed |
| WO-2010042649-A2 | PHTHALAZINE COMPOUNDS AS p38 MAP KINASE MODULATORS AND METHODS OF USE THEREOF | AMGEN INC. (US) | 2010-04-15 | — | — | WO | disclosed |
| WO-2010042646-A1 | AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AS P38 MAP KINASE MODULATORS AND METHODS OF USE THEREOF | AMGEN INC. (US) | 2010-04-15 | — | — | WO | disclosed |
| EP-0746799-A1 | PHOTOTHERMOGRAPHIC ELEMENT WITH CORE-SHELL-TYPE SILVER HALIDE GRAINS | Imation Corp (a Delaware Corporation) (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1995022785-A1 | PHOTOTHERMOGRAPHIC ELEMENT WITH CORE-SHELL-TYPE SILVER HALIDE GRAINS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1995-08-24 | — | — | WO | disclosed |
| US-4237215-A | DECOMPOSING N-HALO COMPOUND IN PRESENCE OF ORGANIC SILVER SALT TO PRODUCE SILVER HALIDE | FUJI PHOTO FILM CO., LTD. (JP) | 1980-12-02 | — | — | US | disclosed |
| US-4207112-A | STORAGE STABILITY | FUJI PHOTO FILM CO., LTD. (JP) | 1980-06-10 | — | — | US | disclosed |
| US-4144072-A | CONTAINING A PHTHALAZINONE AND A PHTHALIMIDE | FUJI PHOTO FILM CO., LTD. (JP) | 1979-03-13 | — | — | US | disclosed |
| US-4125403-A | ORGANIC SILVER SALT, SILVER HALIDE, REDUCING AGENT, PHTHALAZINONE, AND A BENZOXAZINEDIONE OR QUINAZOLINEDIONE | FUJI PHOTO FILM CO., LTD. | 1978-11-14 | — | — | US | disclosed |
| US-4076534-A | Heat developable light-sensitive material | FUJI PHOTO FILM CO., LTD. (JA) | 1978-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180044330-A1 | PHTHALAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | CFTR, SLC26A4, PKD2 | S100A4 4458/4885MEN1 3019/4885KMT2A 3259/4885 |
| US-10889576-B2 | Phthalazinone compounds and methods for the treatment of cystic fibrosis | CFTR, SLC26A4, PKD2 | S100A4 4458/4885MEN1 3019/4885KMT2A 3259/4885 |
| US-10280160-B2 | Phthalazinone compounds and methods for the treatment of cystic fibrosis | CFTR, SLC26A4, PKD2 | S100A4 4458/4885MEN1 3019/4885KMT2A 3259/4885 |
| US-20180093976-A1 | PYRIDAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | CFTR, SLC26A4, PNPO | S100A4 3432/4885MEN1 3222/4885KMT2A 3934/4885 |
| US-20120040983-A1 | Phthalazine Compounds as P38 Map Kinase Modulators and Methods of Use Thereof | MAPK1, MAPK4, MAPK12 | S100A4 1014/4885MEN1 4582/4885KMT2A 2665/4885 |
| US-10370366-B2 | Pyridazinone compounds and methods for the treatment of cystic fibrosis | CFTR, SLC26A4, PNPO | S100A4 3432/4885MEN1 3222/4885KMT2A 3934/4885 |
| US-20190256505-A1 | PHTHALAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | CFTR, SLC26A4, PKD2 | S100A4 4458/4885MEN1 3019/4885KMT2A 3259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.