Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | MST1R | Q04912 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 3/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.34 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.34 |
| ▸ | NEK7 | Q8TDX7 | 1/20 | 0.34 |
| ▸ | NEK6 | Q9HC98 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7667490 | 0.74 | MAP3K11 (0.32) | MAP3K11TLK2NEK7NEK6 | |
| SCHEMBL25757654 | 0.74 | CLK4 (0.42) | DYRK1ACLK4CDK5LTKMST1R | |
| SCHEMBL25757652 | 0.69 | CDK5 (0.41) | DYRK1ACLK4CDK5LTKMST1R | |
| SCHEMBL31451620 | 0.69 | CDK5 (0.41) | DYRK1ACLK4CDK5LTKMST1R | |
| SCHEMBL16335317 | 0.68 | DYRK1A (0.40) | DYRK1ACLK4CDK5LTKMST1R | |
| SCHEMBL5873762 | 0.68 | MAP3K11 (0.40) | DYRK1ACLK4CDK5DYRK1BMAP3K11 | |
| SCHEMBL2722669 | 0.67 | ALDH1A1 (0.46) | DYRK1AMAP3K11TLK2NEK7NEK6 | |
| SCHEMBL12321662 | 0.67 | NOTUM (0.41) | MAP3K11TLK2NEK7NEK6ACHE | |
| SCHEMBL807493 | 0.66 | MAP3K11 (0.38) | DYRK1ACLK4CDK5LTKDYRK1B | |
| SCHEMBL6807733 | 0.66 | DYRK1A (0.41) | DYRK1ACLK4CDK5LTKMST1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559815-B1 | OPTICALLY ACTIVE THIAZOLOISOINDOLINONE DERIVATIVES WITH AN ANTIVIRAL ACTION | BOEHRINGER MANNHEIM GMBH (DE) | 1995-09-06 | — | — | EP | claimed |
| EP-0559815-A1 | OPTICALLY ACTIVE THIAZOLOISOINDOLINONE DERIVATIVES WITH AN ANTIVIRAL ACTION. | BOEHRINGER MANNHEIM GMBH (DE) | 1993-09-15 | — | — | EP | claimed |
| WO-1992009606-A1 | OPTICALLY ACTIVE THIAZOLOISOINDOLINONE DERIVATIVES WITH AN ANTIVIRAL ACTION | BOEHRINGER MANNHEIM GMBH (DE) | 1992-06-11 | — | — | WO | claimed |
| US-9861652-B2 | 2′ Fluoronucleosides | EMORY UNIVERSITY (US) | 2018-01-09 | — | — | US | disclosed |
| US-20160158266-A1 | 2' FLUORONUCLEOSIDES | EMORY UNIVERSITY | 2016-06-09 | — | — | US | disclosed |
| US-9180138-B2 | 2′-fluoronucleosides | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2015-11-10 | — | — | US | disclosed |
| US-20130157971-A1 | 2'-FLUORONUCLEOSIDES | SCHINAZI RAYMOND F (US) | 2013-06-20 | — | — | US | disclosed |
| US-20130018018-A1 | NOVEL NUCLEOSIDE PHOSPHONATES AND ANALOGS | Epiphany Biosciences ,Inc. (US) | 2013-01-17 | — | — | US | disclosed |
| US-8222257-B2 | Phosphono-pent-2-en-1-yl nucleosides and analogs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-07-17 | — | — | US | disclosed |
| EP-2470194-A1 | NOVEL NUCLEOSIDE PHOSPHONATES AND ANALOGS | Epiphany Biosciences Inc. (US) | 2012-07-04 | — | — | EP | disclosed |
| US-8168583-B2 | 2-fluoronucleosides | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2012-05-01 | — | — | US | disclosed |
| US-5397794-A | Treatment of retrovirus | BOEHRINGER MANNHEIM GMBH (DE) | 1995-03-14 | — | — | US | disclosed |
| US-5397794-A | Treatment of retrovirus | BOEHRINGER MANNHEIM GMBH (DE) | 1995-03-14 | — | — | US | disclosed |
| EP-0556245-B1 | USE OF THIAZOLO-ISOINDOLINONE DERIVATIVES AS ANTIVIRAL MEDICAMENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1995-01-25 | — | — | EP | disclosed |
| EP-0559815-A1 | OPTICALLY ACTIVE THIAZOLOISOINDOLINONE DERIVATIVES WITH AN ANTIVIRAL ACTION. | BOEHRINGER MANNHEIM GMBH (DE) | 1993-09-15 | — | — | EP | disclosed |
| EP-0559815-A1 | OPTICALLY ACTIVE THIAZOLOISOINDOLINONE DERIVATIVES WITH AN ANTIVIRAL ACTION. | BOEHRINGER MANNHEIM GMBH (DE) | 1993-09-15 | — | — | EP | disclosed |
| EP-0556245-A1 | USE OF THIAZOLO-ISOINDOLINONE DERIVATIVES AS ANTIVIRAL MEDICAMENTS. | BOEHRINGER MANNHEIM GMBH (DE) | 1993-08-25 | — | — | EP | disclosed |
| WO-1992009606-A1 | OPTICALLY ACTIVE THIAZOLOISOINDOLINONE DERIVATIVES WITH AN ANTIVIRAL ACTION | BOEHRINGER MANNHEIM GMBH (DE) | 1992-06-11 | — | — | WO | disclosed |
| WO-1992009606-A1 | OPTICALLY ACTIVE THIAZOLOISOINDOLINONE DERIVATIVES WITH AN ANTIVIRAL ACTION | BOEHRINGER MANNHEIM GMBH (DE) | 1992-06-11 | — | — | WO | disclosed |
| WO-1992008457-A1 | USE OF THIAZOLO-ISOINDOLINONE DERIVATIVES AS ANTIVIRAL MEDICAMENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1992-05-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018018-A1 | NOVEL NUCLEOSIDE PHOSPHONATES AND ANALOGS | PNP, TYMP, ENTPD5 | DYRK1A 4183/4885CLK4 3774/4885CDK5 357/4885 |
| US-20160158266-A1 | 2' FLUORONUCLEOSIDES | PNP, BCL3, NPC1 | DYRK1A 4705/4885CLK4 4187/4885CDK5 3294/4885 |
| US-20130157971-A1 | 2'-FLUORONUCLEOSIDES | PNP, BCL3, FUBP3 | DYRK1A 4741/4885CLK4 4293/4885CDK5 3386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.