Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.41 |
| ▸ | PIM1 | P11309 | 3/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | MST1R | Q04912 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.32 |
| ▸ | PLK4 | O00444 | 2/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.32 |
| ▸ | FLT4 | P35916 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31451620 | 0.73 | CDK5 (0.41) | DYRK1ACLK4PIM1ROCK1CDK5 | |
| SCHEMBL25757652 | 0.73 | CDK5 (0.41) | DYRK1ACLK4PIM1ROCK1CDK5 | |
| SCHEMBL5873807 | 0.68 | AHR (0.35) | CDK5GSK3AGSK3BCDK2 | |
| SCHEMBL599458 | 0.66 | DYRK1A (0.42) | DYRK1ACLK4PIM1ROCK1CDK5 | |
| SCHEMBL16335317 | 0.66 | DYRK1A (0.40) | DYRK1ACLK4PIM1ROCK1CDK5 | |
| SCHEMBL18022667 | 0.63 | MEN1 (0.46) | DYRK1ACLK4PIM1ROCK1CDK5 | |
| SCHEMBL5893935 | 0.62 | CES1 (0.44) | DYRK1ACLK4PIM1ROCK1CDK5 | |
| SCHEMBL5893583 | 0.62 | CES1 (0.44) | CA12CA9MAP3K11 | |
| SCHEMBL25134030 | 0.62 | ROCK1 (0.47) | DYRK1ACLK4PIM1ROCK1CDK5 | |
| SCHEMBL11450232 | 0.62 | CDK5 (0.47) | DYRK1ACLK4PIM1ROCK1CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040092539-A1 | Substituted 6-benzyl-4-oxopyrimidines, process for their preparation and pharmaceutical compositions containing them | COLLA PAOLO LA (IT) | 2004-05-13 | — | — | US | claimed |
| CN-1309647-A | Substd. 6-benzyl-4-oxopyrimidines, process for their preparation and pharmaceutical compositions contg. them | NOVIRIO PHARMACEUTICALS LTD (KY) | 2001-08-22 | — | — | CN | claimed |
| EP-1098887-A1 | SUBSTITUTED 6-BENZYL-4-OXOPYRIMIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Novirio Pharmaceuticals Limited (KY) | 2001-05-16 | — | — | EP | claimed |
| WO-2000003998-A1 | SUBSTITUTED 6-BENZYL-4-OXOPYRIMIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NOVIRIO PHARMACEUTICALS LIMITED (KY) | 2000-01-27 | — | — | WO | claimed |
| US-6602664-B2 | Treatment of HIV-infected human in alternation or combination with second anti-HIV drug that induces mutation pattern at other than 70th codon of reverse transcriptase region location; drug resistance, pharmokinetics | EMORY UNIVERSITY | 2003-08-05 | — | — | US | disclosed |
| US-20010009906-A1 | Use of 3'-azido-2' ,3' -dideoxyuridine | SCHINAZI RAYMOND F (US) | 2001-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010009906-A1 | Use of 3'-azido-2' ,3' -dideoxyuridine | NSUN2, DUT, DUS2 | DYRK1A 1504/4885CLK4 2638/4885PIM1 1821/4885 |
| US-20040092539-A1 | Substituted 6-benzyl-4-oxopyrimidines, process for their preparation and pharmaceutical compositions containing them | TYMP, UMPS, TYMS | DYRK1A 4654/4885CLK4 4650/4885PIM1 1802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.