Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 18/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.75 |
| ▸ | GLA | P06280 | 3/20 | 0.75 |
| ▸ | RECQL | P46063 | 2/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.75 |
| ▸ | MEN1 | O00255 | 2/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | RAB9A | P51151 | 2/20 | 0.71 |
| ▸ | BLM | P54132 | 2/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 2/20 | 0.68 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.68 |
| ▸ | ACHE | P22303 | 1/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.68 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.68 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7262301 | 0.90 | TOP1 (0.65) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL17897650 | 0.88 | TOP1 (0.85) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL1004508 | 0.88 | TOP1 (1.00) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL27827045 | 0.88 | TOP1 (1.00) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL7258450 | 0.88 | TOP1 (0.71) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL7262917 | 0.87 | TOP1 (0.71) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL14009606 | 0.87 | TOP1 (0.74) | TOP1ALDH1A1GLARECQLTDP1 | |
| Hydrochloric Acid SCHEMBL28012447 | 0.87 | TOP1 (0.97) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL2480193 | 0.86 | TOP1 (0.75) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL8484508 | 0.86 | TOP1 (0.69) | TOP1ALDH1A1GLARECQLTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1270579-B1 | PROCESS FOR PRODUCING CAMPTOTHECIN | YAKULT HONSHA KK (JP) | 2006-05-31 | — | — | EP | disclosed |
| US-6743918-B2 | HYDROLYZING 9-METHOXYCAMPTOTHECIN; 9-O-PERFLUORO-ALKYL-SULFONYLATION OR 9-O-PHENYLTETRAZOLYLATION FOLLOWED BY HYDROGENOLYSIS; LOW COST; SIMPLE | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2004-06-01 | — | — | US | disclosed |
| US-20040087609-A1 | PROCESS FOR PRODUCING CAMPTOTHECIN | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2004-05-06 | — | — | US | disclosed |
| EP-0777670-B1 | SUBSTITUTED CAMPTOTHECIN DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA ITALIA SPA (IT) | 2004-03-24 | — | — | EP | disclosed |
| EP-0968213-B1 | ALKYNYL-SUBSTITUTED CAMPTOTHECINS AND PROCESS FOR THEIR PREPARATION | PHARMACIA ITALIA SPA (IT) | 2003-01-22 | — | — | EP | disclosed |
| EP-1270579-A1 | PROCESS FOR PRODUCING CAMPTOTHECIN | Kabushiki Kaisha Yakult Honsha (JP) | 2003-01-02 | — | — | EP | disclosed |
| US-6420379-B1 | ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-07-16 | — | — | US | disclosed |
| US-6211192-B1 | ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2001-04-03 | — | — | US | disclosed |
| EP-0968213-A1 | ALKYNYL-SUBSTITUTED CAMPTOTHECINS AND PROCESS FOR THEIR PREPARATION | Pharmacia & Upjohn S.p.A. (IT) | 2000-01-05 | — | — | EP | disclosed |
| US-5856333-A | ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-01-05 | — | — | US | disclosed |
| WO-1998035969-A1 | ALKYNYL-SUBSTITUTED CAMPTOTHECINS AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.P.A. (IT) | 1998-08-20 | — | — | WO | disclosed |
| EP-0777670-A1 | SUBSTITUTED CAMPTOTHECIN DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996037496-A1 | SUBSTITUTED CAMPTOTHECIN DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.P.A. (IT) | 1996-11-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040087609-A1 | PROCESS FOR PRODUCING CAMPTOTHECIN | PFAS, TOP2A, TOP2B | TOP1 4/4885ALDH1A1 3180/4885GLA 3277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.