Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | HTR5A | P47898 | 3/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | PRNP | P04156 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16896923 | 0.84 | OTUD7B (0.55) | OTUD7BALDH1A1CYP3A4THRBMAPK1 | |
| SCHEMBL7434341 | 0.84 | OTUD7B (0.49) | OTUD7BALDH1A1CYP3A4THRBMAPK1 | |
| SCHEMBL6000884 | 0.80 | MAOB (0.50) | — | |
| SCHEMBL6000875 | 0.78 | LMNA (0.41) | ALDH1A1CYP3A4PGROPRM1OPRK1 | |
| SCHEMBL703728 | 0.78 | MAOB (0.58) | PDE3BPDE3AEIF2AK2 | |
| SCHEMBL29724095 | 0.78 | MAOB (0.58) | PDE3BPDE3AEIF2AK2 | |
| SCHEMBL5999174 | 0.77 | PDE3B (0.59) | OTUD7BALDH1A1SRCPDE3BPDE3A | |
| SCHEMBL7430923 | 0.77 | ALDH1A1 (0.49) | OTUD7BALDH1A1CYP3A4THRBMAPK1 | |
| SCHEMBL886664 | 0.76 | PDE7A (0.51) | ALDH1A1CYP3A4THRBMAPK1PDE3B | |
| SCHEMBL30089469 | 0.75 | CYP3A4 (0.52) | ALDH1A1CYP3A4THRBMAPK1HTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060234997-A1 | Tetrahydro-pyridoazepin-8-ones and related compounds for the treatment of schizophrenia | WARNER-LAMBERT COMPANY LLC | 2006-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060234997-A1 | Tetrahydro-pyridoazepin-8-ones and related compounds for the treatment of schizophrenia | PTGDR, GRIN2A, PTGDR2 | OTUD7B 3928/4885ALDH1A1 826/4885CYP3A4 542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.