SCHEMBL6001081

SCHEMBL6001081

[CH2]c1cccc(-c2ccccc2)c1OC(F)(F)F

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
METAP2 P50579 1/20 0.36
SCN9A Q15858 5/20 0.35
L3MBTL1 Q9Y468 2/20 0.34
KDM4E B2RXH2 1/20 0.34
MAPT P10636 1/20 0.34
FFAR4 Q5NUL3 1/20 0.34
ENPP1 P22413 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
GPR3 P46089 1/20 0.33
ALDH1A1 P00352 3/20 0.32
HSD17B10 Q99714 2/20 0.32
HPGD P15428 1/20 0.32
BCL2L1 Q07817 1/20 0.32
CYP2A6 P11509 1/20 0.32
MAPK1 P28482 1/20 0.32
HCRTR1 O43613 1/20 0.32
HCRTR2 O43614 1/20 0.32
ADORA2A P29274 1/20 0.32
ADORA1 P30542 1/20 0.32
TACR1 P25103 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27907835 0.80 METAP2 (0.37) METAP2SCN9AL3MBTL1KDM4EMAPT
SCHEMBL25219191 0.80 SCN9A (0.46) SCN9AL3MBTL1KDM4EMAPTFFAR4
SCHEMBL27907871 0.79 CYP2A6 (0.50) METAP2SCN9AL3MBTL1KDM4EMAPT
SCHEMBL27926071 0.79 ALDH1A1 (0.50) METAP2SCN9AL3MBTL1KDM4EMAPT
SCHEMBL30583087 0.79 CYP2A6 (0.50) METAP2SCN9AL3MBTL1KDM4EMAPT
SCHEMBL3952356 0.79 ALDH1A1 (0.50) METAP2SCN9AL3MBTL1KDM4EMAPT
SCHEMBL27699820 0.76 PDCD1 (0.50) METAP2SCN9AL3MBTL1MAPTFFAR4
SCHEMBL6991452 0.75 AR (0.44) KDM4EALDH1A1HPGDADORA2AADORA1
SCHEMBL4032566 0.75 LMNA (0.38) METAP2SCN9AL3MBTL1FFAR4TDP1
SCHEMBL27818669 0.75 HNF4A (0.53) L3MBTL1MAPTFFAR4TDP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1678185-A1 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2006-07-12 EP disclosed
WO-2005042542-A1 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2005-05-12 WO disclosed