Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.49 |
| ▸ | CLK1 | P49759 | 3/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.49 |
| ▸ | CES1 | P23141 | 2/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.46 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23041056 | 0.89 | DYRK1A (0.58) | POLBMAPK1DYRK1ACLK1DYRK1B | |
| SCHEMBL6001679 | 0.84 | DYRK1A (0.67) | MAPK1DYRK1ACLK1DYRK1BLMNA | |
| SCHEMBL10514999 | 0.82 | DYRK1A (0.65) | POLBMAPK1DYRK1ACLK1DYRK1B | |
| SCHEMBL6001663 | 0.79 | CNR2 (0.51) | DYRK1ACLK1DYRK1BMAOBLMNA | |
| SCHEMBL6000839 | 0.73 | CYP1A2 (0.54) | DYRK1ACLK1DYRK1BGAAHSD17B1 | |
| SCHEMBL6001482 | 0.72 | ERO1A (0.47) | POLBMAPK1CES1SRD5A2CES2 | |
| SCHEMBL229627 | 0.71 | POLB (0.82) | POLBMAPK1CES1SRD5A2CES2 | |
| Benzophenone SCHEMBL28231509 | 0.71 | POLB (0.82) | POLBMAPK1CES1SRD5A2CES2 | |
| SCHEMBL31232930 | 0.71 | ALDH1A1 (0.54) | POLBLMNAGAAALDH1A1MAPT | |
| SCHEMBL9523531 | 0.71 | ALDH1A1 (0.54) | POLBLMNAGAAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060142271-A1 | Novel lapacho compounds and methods of use thereof | MUNSTER, UNIVERSITY OF (DE) | 2006-06-29 | — | — | US | disclosed |
| EP-1551392-A2 | NOVEL LAPACHO COMPOUNDS AND METHODS OF USE THEREOF | ARQULE, INC. (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004026253-A2 | NOVEL LAPACHO COMPOUNDS AND METHODS OF USE THEREOF | ARQULE, INC. (US) | 2004-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142271-A1 | Novel lapacho compounds and methods of use thereof | XIAP, PIN1, NQO1 | POLB 1759/4885MAPK1 1284/4885DYRK1A 3249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.