Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | BRPF1 | P55201 | 4/20 | 0.39 |
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | BRD1 | O95696 | 3/20 | 0.39 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.39 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.39 |
| ▸ | ECE1 | P42892 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6001817 | 0.87 | MAPK1 (0.43) | SMN1; SMN2MAPK1BRPF1BRD4BRD1 | |
| SCHEMBL6001539 | 0.82 | RXFP1 (0.57) | SMN1; SMN2MAPK1NPC1ECE1MEN1 | |
| SCHEMBL6001987 | 0.80 | SMN1; SMN2 (0.41) | SMN1; SMN2MAPK1BRPF1BRD4BRD1 | |
| SCHEMBL6000176 | 0.76 | KDM4E (0.55) | SMN1; SMN2MAPK1BRPF1BRD4BRD1 | |
| SCHEMBL6001777 | 0.74 | SMN1; SMN2 (0.42) | SMN1; SMN2MAPK1NPC1BRD4CA2 | |
| SCHEMBL6002292 | 0.73 | SERPINE1 (0.48) | ECE1 | |
| SCHEMBL6000253 | 0.73 | RXFP1 (0.48) | SMN1; SMN2NPC1ECE1SRCMEN1 | |
| SCHEMBL6001714 | 0.71 | MAPT (0.51) | SMN1; SMN2MAPK1BRPF1RXFP1MAPT | |
| SCHEMBL6002268 | 0.71 | MAPK1 (0.38) | SMN1; SMN2MAPK1ECE1CA2 | |
| SCHEMBL6002238 | 0.69 | CACNA1B (0.40) | SMN1; SMN2MAPK1BRPF1ECE1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212296-B9 | PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS | SUGEN INC (US) | 2006-05-10 | — | — | EP | claimed |
| EP-1212296-B1 | PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS | SUGEN INC (US) | 2005-11-09 | — | — | EP | claimed |