Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6001840 | 0.89 | CACNA1B (0.40) | CACNA1BMAPK1SMN1; SMN2ECE1PSEN1 | |
| SCHEMBL6002268 | 0.88 | MAPK1 (0.38) | MAPK1SMN1; SMN2ECE1PTPN11EPHX2 | |
| SCHEMBL6002236 | 0.86 | SERPINE1 (0.43) | CACNA1BMAPK1SMN1; SMN2ECE1PSEN1 | |
| SCHEMBL6001790 | 0.86 | CACNA1B (0.44) | CACNA1BMAPK1SMN1; SMN2ECE1PSEN1 | |
| SCHEMBL6002292 | 0.81 | SERPINE1 (0.48) | ECE1SERPINE1 | |
| SCHEMBL6000254 | 0.81 | MEN1 (0.41) | CACNA1BSMN1; SMN2ECE1ALDH1A1KDM4E | |
| SCHEMBL6001817 | 0.80 | MAPK1 (0.43) | MAPK1SMN1; SMN2PTPN11PTPN1BRPF1 | |
| SCHEMBL6002334 | 0.78 | SMN1; SMN2 (0.39) | MAPK1SMN1; SMN2ECE1PTPN11EPHX2 | |
| SCHEMBL6002233 | 0.78 | ECE1 (0.43) | MAPK1SMN1; SMN2ECE1EPHX2ALDH1A1 | |
| SCHEMBL6001802 | 0.73 | MAPK1 (0.43) | MAPK1SMN1; SMN2ECE1PTPN11EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212296-B9 | PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS | SUGEN INC (US) | 2006-05-10 | — | — | EP | claimed |
| EP-1212296-B1 | PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS | SUGEN INC (US) | 2005-11-09 | — | — | EP | claimed |