Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | BRPF1 | P55201 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6002334 | 0.86 | SMN1; SMN2 (0.39) | SMN1; SMN2MAPK1BRPF1MAPTMMP2 | |
| SCHEMBL6001817 | 0.85 | MAPK1 (0.43) | SMN1; SMN2MAPK1BRPF1HDAC8HDAC1 | |
| SCHEMBL6001714 | 0.83 | MAPT (0.51) | SMN1; SMN2MAPK1BRPF1KDM4ECYP1A2 | |
| SCHEMBL6001840 | 0.83 | CACNA1B (0.40) | SMN1; SMN2MAPK1BRPF1MAPTMMP2 | |
| SCHEMBL6002337 | 0.81 | ECE1 (0.41) | SMN1; SMN2MAPK1BRPF1LMNAALDH1A1 | |
| SCHEMBL6001828 | 0.80 | SMN1; SMN2 (0.43) | SMN1; SMN2MAPK1BRPF1MAPTMEN1 | |
| SCHEMBL9238606 | 0.77 | KDM4E (0.50) | SMN1; SMN2KDM4ECYP1A2CYP3A4CYP2C19 | |
| SCHEMBL9237671 | 0.77 | LMNA (0.50) | KDM4ECYP1A2CYP3A4CYP2C19LMNA | |
| SCHEMBL6000176 | 0.75 | KDM4E (0.55) | SMN1; SMN2MAPK1BRPF1KDM4EHDAC8 | |
| SCHEMBL6001895 | 0.73 | POLB (0.47) | SMN1; SMN2MAPK1KDM4EMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212296-B9 | PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS | SUGEN INC (US) | 2006-05-10 | — | — | EP | claimed |
| EP-1212296-B1 | PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS | SUGEN INC (US) | 2005-11-09 | — | — | EP | claimed |