Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 2/20 | 0.43 |
| ▸ | RORA | P35398 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | RORB | Q92753 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 9/20 | 0.35 |
| ▸ | CNR1 | P21554 | 5/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | FABP3 | P05413 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6002337 | 0.88 | ECE1 (0.41) | ECE1RORARORCRORBCNR2 | |
| SCHEMBL6002221 | 0.85 | ECE1 (0.52) | ECE1RORARORCRORBCNR2 | |
| SCHEMBL6002268 | 0.83 | MAPK1 (0.38) | ECE1MAPK1SMN1; SMN2EPHX2 | |
| SCHEMBL6002242 | 0.80 | ECE1 (0.47) | ECE1RORCCNR2CNR1MAPK1 | |
| SCHEMBL6002292 | 0.80 | SERPINE1 (0.48) | ECE1PPARG | |
| SCHEMBL6002238 | 0.78 | CACNA1B (0.40) | ECE1BRPF1MAPK1SMN1; SMN2EPHX2 | |
| SCHEMBL6001817 | 0.77 | MAPK1 (0.43) | BRPF1MAPK1SMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL6002334 | 0.72 | SMN1; SMN2 (0.39) | ECE1BRPF1MAPK1SMN1; SMN2EPHX2 | |
| SCHEMBL6001713 | 0.69 | SERPINE1 (0.49) | ECE1MAPK1SMN1; SMN2 | |
| SCHEMBL6001802 | 0.69 | MAPK1 (0.43) | ECE1BRPF1MAPK1SMN1; SMN2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212296-B9 | PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS | SUGEN INC (US) | 2006-05-10 | — | — | EP | claimed |
| EP-1212296-B1 | PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS | SUGEN INC (US) | 2005-11-09 | — | — | EP | claimed |