Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | ECE1 | P42892 | 1/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6001840 | 0.89 | CACNA1B (0.40) | SMN1; SMN2MAPK1ECE1BRPF1ALDH1A1 | |
| SCHEMBL6002268 | 0.88 | MAPK1 (0.38) | SMN1; SMN2MAPK1PTGDR2ECE1SERPINE1 | |
| SCHEMBL6001987 | 0.86 | SMN1; SMN2 (0.41) | SMN1; SMN2MAPK1BRPF1ALDH1A1MMP2 | |
| SCHEMBL6001895 | 0.84 | POLB (0.47) | SMN1; SMN2MAPK1ECE1SERPINE1ALDH1A1 | |
| SCHEMBL6002337 | 0.83 | ECE1 (0.41) | SMN1; SMN2MAPK1ECE1BRPF1ALDH1A1 | |
| SCHEMBL6001802 | 0.82 | MAPK1 (0.43) | SMN1; SMN2MAPK1PTGDR2AKR1B1ECE1 | |
| SCHEMBL6001985 | 0.81 | PTGDR2 (0.36) | SMN1; SMN2PTGDR2AKR1B1ALDH1A1MEN1 | |
| SCHEMBL6001713 | 0.79 | SERPINE1 (0.49) | SMN1; SMN2MAPK1ECE1SERPINE1 | |
| SCHEMBL6002238 | 0.78 | CACNA1B (0.40) | SMN1; SMN2MAPK1ECE1BRPF1SERPINE1 | |
| SCHEMBL6002292 | 0.75 | SERPINE1 (0.48) | ECE1SERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212296-B9 | PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS | SUGEN INC (US) | 2006-05-10 | — | — | EP | claimed |
| EP-1212296-B1 | PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS | SUGEN INC (US) | 2005-11-09 | — | — | EP | claimed |