Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | CDK9 | P50750 | 1/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6421168 | 0.88 | NAPRT (0.59) | NAPRTHSD17B10SMN1; SMN2MAPTGAA | |
| SCHEMBL2244779 | 0.87 | SMN1; SMN2 (0.61) | NAPRTHSD17B10SMN1; SMN2MAPTGAA | |
| SCHEMBL12606901 | 0.84 | NAPRT (0.55) | NAPRTHSD17B10SMN1; SMN2MAPTGAA | |
| SCHEMBL28216490 | 0.82 | HSD17B10 (0.52) | NAPRTHSD17B10SMN1; SMN2MAPTGAA | |
| SCHEMBL282531 | 0.80 | SMN1; SMN2 (0.71) | NAPRTHSD17B10SMN1; SMN2MAPTGAA | |
| SCHEMBL15638381 | 0.80 | RAB9A (0.54) | NAPRTHSD17B10SMN1; SMN2MAPTGAA | |
| SCHEMBL28049155 | 0.80 | NPC1 (0.59) | HSD17B10SMN1; SMN2MAPTGAAALDH1A1 | |
| SCHEMBL23240942 | 0.79 | SMN1; SMN2 (0.52) | NAPRTHSD17B10SMN1; SMN2MAPTGAA | |
| SCHEMBL9065932 | 0.79 | SMN1; SMN2 (0.52) | NAPRTHSD17B10SMN1; SMN2MAPTGAA | |
| SCHEMBL11717669 | 0.79 | SMN1; SMN2 (0.52) | NAPRTHSD17B10SMN1; SMN2MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |