Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2244779 | 0.89 | SMN1; SMN2 (0.61) | HSD17B10NAPRTSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL28049155 | 0.82 | NPC1 (0.59) | HSD17B10SMN1; SMN2ALDH1A1GAAHTT | |
| SCHEMBL28497934 | 0.82 | TDP1 (0.53) | SMN1; SMN2ALDH1A1RAB9AMAPT | |
| SCHEMBL6421168 | 0.82 | NAPRT (0.59) | HSD17B10NAPRTSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL6002669 | 0.82 | NAPRT (0.59) | HSD17B10NAPRTSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL17479850 | 0.80 | L3MBTL1 (0.52) | HSD17B10NAPRTSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL11411034 | 0.79 | HSD17B10 (0.62) | HSD17B10SMN1; SMN2ALDH1A1KMT2ARAB9A | |
| SCHEMBL282531 | 0.79 | SMN1; SMN2 (0.71) | HSD17B10NAPRTSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL12606901 | 0.78 | NAPRT (0.55) | HSD17B10NAPRTSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL15638381 | 0.78 | RAB9A (0.54) | HSD17B10NAPRTSMN1; SMN2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108069976-A | A kind of nitrogenous macrocyclic compounds, its preparation method, pharmaceutical composition and application | 山东罗欣药业集团股份有限公司 | 2018-05-25 | — | — | CN | disclosed |