Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4826461 | 0.93 | CHEK1 (0.37) | TLR7CSNK1DMAPK14GABRA5 | |
| SCHEMBL6002771 | 0.88 | TP53 (0.41) | TLR7ENPP2HSP90AA1HSP90AB1MAPK10 | |
| Isopropylamine SCHEMBL4826689 | 0.88 | PTPN1 (0.39) | ENPP2CSNK1DMAPK14MAPK10NPC1 | |
| SCHEMBL4790988 | 0.87 | CSNK1D (0.35) | ENPP2CSNK1DMAPK14HSP90AA1HSP90AB1 | |
| SCHEMBL4722400 | 0.86 | TLR7 (0.42) | TLR7CSNK1DMAPK14GABRA5MAPK10 | |
| SCHEMBL6004885 | 0.85 | TLR7 (0.41) | TLR7CSNK1DMAPK14GABRA5MAPK10 | |
| SCHEMBL4762959 | 0.81 | GABRA5 (0.48) | TLR7CSNK1DMAPK14GABRA5MAPK10 | |
| SCHEMBL6004622 | 0.78 | PIN1 (0.44) | PIN1TLR7CSNK1DMAPK14GABRA5 | |
| SCHEMBL4761826 | 0.77 | MAPK14 (0.42) | PIN1TLR7CSNK1DMAPK14GABRA5 | |
| SCHEMBL6004394 | 0.76 | ENPP2 (0.42) | PIN1TLR7ENPP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060252807-A1 | Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders | KALYPSYS, INC. | 2006-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252807-A1 | Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders | MAPK1, MAP3K1, MAPK4 | PIN1 598/4885TLR7 495/4885ENPP2 266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.