Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6002763 | 0.88 | PIN1 (0.40) | MAPK10MAPK14CSNK1DENPP2NPC1 | |
| SCHEMBL4790988 | 0.87 | CSNK1D (0.35) | MAPK10MAPK14CSNK1DENPP2NPC1 | |
| Isopropylamine SCHEMBL4925679 | 0.85 | PTPN1 (0.42) | PTPN1MAPK10PTGER1MAPK14CSNK1D | |
| Isopropylamine SCHEMBL4837081 | 0.84 | PTPN1 (0.42) | PTPN1MAPK10PTGER1MAPK14CSNK1D | |
| SCHEMBL6002771 | 0.83 | TP53 (0.41) | MAPK10ENPP2NPC1RAB9ATP53 | |
| SCHEMBL4826461 | 0.81 | CHEK1 (0.37) | MAPK14CSNK1D | |
| Isopropylamine SCHEMBL4791624 | 0.80 | PTGS2 (0.48) | PTPN1MAPK10PTGER1MAPK14CSNK1D | |
| Isopropylamine SCHEMBL4791416 | 0.77 | LMNA (0.39) | PTPN1PTGER1MAPK14CSNK1DENPP2 | |
| SCHEMBL4762794 | 0.75 | ALDH1A1 (0.51) | PTPN1PTGER1MAPK14ALDH1A1 | |
| SCHEMBL4722400 | 0.73 | TLR7 (0.42) | MAPK10MAPK14CSNK1DNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871770-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | Kalypsys, Inc. (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006116355-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | KALYPSYS, INC. (US) | 2006-11-02 | — | — | WO | disclosed |