Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.41 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 6/20 | 0.35 |
| ▸ | AURKA | O14965 | 5/20 | 0.35 |
| ▸ | TEK | Q02763 | 5/20 | 0.35 |
| ▸ | LCK | P06239 | 4/20 | 0.35 |
| ▸ | MET | P08581 | 3/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 4/20 | 0.34 |
| ▸ | EGFR | P00533 | 3/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | TEC | P42680 | 1/20 | 0.34 |
| ▸ | TXK | P42681 | 1/20 | 0.34 |
| ▸ | BLK | P51451 | 1/20 | 0.34 |
| ▸ | BMX | P51813 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004984 | 0.90 | PDE3B (0.39) | PDE3BPDE3AP2RY12DDR2APP | |
| SCHEMBL6004140 | 0.90 | DDR2 (0.35) | DDR2KDRAURKATEKLCK | |
| SCHEMBL6004910 | 0.89 | DDR2 (0.34) | DDR2KDRAURKATEKLCK | |
| SCHEMBL6004067 | 0.88 | SLC22A12 (0.38) | PDE3BPDE3AP2RY12DDR2KDR | |
| SCHEMBL6004228 | 0.86 | AXL (0.34) | DDR2KDRAURKATEKLCK | |
| SCHEMBL6005256 | 0.84 | PDGFRB (0.36) | DDR2KDRAURKATEKLCK | |
| SCHEMBL6004126 | 0.82 | ROCK2 (0.36) | DDR2KDRAURKATEKLCK | |
| SCHEMBL6004179 | 0.81 | CYP3A4 (0.44) | — | |
| SCHEMBL6004233 | 0.80 | SRC (0.34) | BTKEGFRERBB2TECTXK | |
| SCHEMBL6004207 | 0.78 | CYP1A2 (0.37) | DDR2KDRMETBTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |