Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 4/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
| ▸ | ESRRB | O95718 | 2/20 | 0.33 |
| ▸ | ESRRA | P11474 | 2/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004082 | 0.88 | CBFB (0.37) | SRCTGFBR1ALDH1A1MEN1CASP1 | |
| SCHEMBL6004146 | 0.85 | SRC (0.38) | SRCTGFBR1ALDH1A1MEN1CASP1 | |
| SCHEMBL6005293 | 0.85 | THRB (0.36) | TGFBR1 | |
| SCHEMBL6004067 | 0.84 | SLC22A12 (0.38) | PDGFRBPDGFRAEGFRBTKERBB2 | |
| SCHEMBL6005256 | 0.84 | PDGFRB (0.36) | PDGFRBPDGFRAEGFRBTKERBB2 | |
| SCHEMBL6004179 | 0.83 | CYP3A4 (0.44) | ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL6005275 | 0.83 | PDGFRB (0.52) | SRCTGFBR1PDGFRBPDGFRAEGFR | |
| SCHEMBL6004228 | 0.82 | AXL (0.34) | ALDH1A1CASP1CASP7PDGFRBPDGFRA | |
| SCHEMBL6004288 | 0.81 | KDR (0.41) | SRCTGFBR1 | |
| SCHEMBL6003010 | 0.80 | PDE3B (0.41) | SRCTGFBR1MEN1KMT2AEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |