Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | TEC | P42680 | 1/20 | 0.32 |
| ▸ | TXK | P42681 | 1/20 | 0.32 |
| ▸ | BLK | P51451 | 1/20 | 0.32 |
| ▸ | BMX | P51813 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 4/20 | 0.32 |
| ▸ | MET | P08581 | 3/20 | 0.32 |
| ▸ | AURKA | O14965 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004067 | 0.90 | SLC22A12 (0.38) | AXLPDGFRBPDGFRADDR2EGFR | |
| SCHEMBL6005256 | 0.88 | PDGFRB (0.36) | PDGFRBPDGFRADDR2EGFRERBB2 | |
| SCHEMBL6003010 | 0.86 | PDE3B (0.41) | DDR2EGFRERBB2TECTXK | |
| SCHEMBL6004179 | 0.85 | CYP3A4 (0.44) | ALDH1A1HSD17B10 | |
| SCHEMBL6004126 | 0.84 | ROCK2 (0.36) | AXLDDR2ALDH1A1EGFRERBB2 | |
| SCHEMBL6004140 | 0.84 | DDR2 (0.35) | AXLDDR2EGFRERBB2TEC | |
| SCHEMBL6004233 | 0.82 | SRC (0.34) | PDGFRBPDGFRAALDH1A1CASP1CASP7 | |
| SCHEMBL6004910 | 0.82 | DDR2 (0.34) | AXLDDR2EGFRERBB2TEC | |
| SCHEMBL6005293 | 0.81 | THRB (0.36) | HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL6004207 | 0.80 | CYP1A2 (0.37) | AXLDDR2ALDH1A1EGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |