Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4826133 | 0.83 | ALDH1A1 (0.62) | RAB9ANPC1SMN1; SMN2NPSR1MAPT | |
| SCHEMBL19941430 | 0.81 | RAB9A (0.55) | RAB9ANPC1SMN1; SMN2NPSR1MAPT | |
| SCHEMBL513735 | 0.80 | RAB9A (0.62) | RAB9ANPC1SMN1; SMN2NPSR1MAPT | |
| SCHEMBL2091531 | 0.80 | HTT (0.51) | RAB9ANPC1SMN1; SMN2MAPTPOLB | |
| SCHEMBL19938055 | 0.80 | NPC1 (0.54) | RAB9ANPC1SMN1; SMN2NPSR1MAPT | |
| SCHEMBL6002183 | 0.79 | ALDH1A1 (0.43) | RAB9ANPC1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL13032946 | 0.79 | MAPT (0.52) | RAB9ANPC1SMN1; SMN2NPSR1MAPT | |
| SCHEMBL513736 | 0.78 | RAB9A (0.64) | RAB9ANPC1SMN1; SMN2NPSR1MAPT | |
| SCHEMBL10415979 | 0.78 | SMN1; SMN2 (0.66) | RAB9ANPC1SMN1; SMN2NPSR1MAPT | |
| SCHEMBL734966 | 0.77 | ALDH1A1 (0.72) | RAB9ANPC1MAPTPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |