Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6002262 | 0.94 | TSHR (0.44) | TSHRTDP1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL6002761 | 0.94 | TSHR (0.44) | TSHRTDP1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL6002685 | 0.94 | TSHR (0.44) | TSHRTDP1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL6002357 | 0.94 | TSHR (0.44) | TSHRTDP1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL6003625 | 0.86 | L3MBTL1 (0.49) | TSHRTDP1L3MBTL1KMT2AALDH1A1 | |
| SCHEMBL6002982 | 0.84 | TSHR (0.46) | TSHRTDP1L3MBTL1KMT2AALDH1A1 | |
| SCHEMBL6002978 | 0.83 | TSHR (0.45) | TSHRTDP1L3MBTL1KMT2AALDH1A1 | |
| SCHEMBL8395345 | 0.81 | TSHR (0.44) | TSHRTDP1L3MBTL1KMT2AALDH1A1 | |
| SCHEMBL8395346 | 0.81 | CYP3A4 (0.44) | TSHRTDP1L3MBTL1KMT2AALDH1A1 | |
| SCHEMBL6002265 | 0.81 | KMT2A (0.47) | TSHRTDP1L3MBTL1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |