Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18554188 | 0.95 | CYP3A4 (0.50) | CYP3A4LMNAKMT2AMEN1NR1I2 | |
| SCHEMBL27399370 | 0.94 | LMNA (0.52) | CYP3A4LMNAKMT2AMEN1NR1I2 | |
| Formaldehyde SCHEMBL28509743 | 0.92 | CYP3A4 (0.48) | CYP3A4LMNAKMT2AMEN1NR1I2 | |
| SCHEMBL6002982 | 0.87 | TSHR (0.46) | CYP3A4LMNAKMT2ATSHRTDP1 | |
| SCHEMBL6002978 | 0.85 | TSHR (0.45) | CYP3A4LMNAKMT2ATSHRTDP1 | |
| SCHEMBL8395345 | 0.84 | TSHR (0.44) | CYP3A4LMNAKMT2ATSHRTDP1 | |
| SCHEMBL8396605 | 0.84 | ALDH1A1 (0.43) | CYP3A4LMNAKMT2AMEN1NR1I2 | |
| SCHEMBL5510643 | 0.83 | ALDH1A1 (0.44) | LMNAKMT2AMEN1MAPTTSHR | |
| SCHEMBL6003625 | 0.83 | L3MBTL1 (0.49) | CYP3A4KMT2ACHRM2MAPTTSHR | |
| SCHEMBL6001172 | 0.82 | TSHR (0.47) | CYP3A4LMNAKMT2AMEN1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |