Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 12/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 12/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 12/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 12/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.50 |
| ▸ | ALPL | P05186 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | XDH | P47989 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6002459 | 0.96 | KDM4E (0.51) | CYP2D6CYP19A1CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL17625952 | 0.87 | NQO1 (0.47) | ALPLHPGDRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL1317405 | 0.78 | NPC1 (0.46) | ALPLHPGDRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL6002253 | 0.76 | MAPT (0.36) | MAPTXDH | |
| SCHEMBL27554388 | 0.75 | METAP2 (0.47) | ALPLHPGDRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL16439282 | 0.74 | CYP19A1 (0.58) | CYP2D6CYP19A1CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL4724249 | 0.74 | CYP19A1 (0.56) | CYP2D6CYP19A1CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL5583851 | 0.73 | CYP2D6 (0.76) | CYP2D6CYP19A1CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL9151170 | 0.73 | CYP2D6 (0.76) | CYP2D6CYP19A1CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL4919062 | 0.73 | CYP2D6 (0.36) | CYP2D6CYP19A1CYP2C9CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |