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Beclamide

Beclamide

SCHEMBL6004229

COc1cc2nccc(Oc3cc4c(nc3-c3ccccc3)NCCC4)c2cc1C(=O)O.O=C(CCCl)NCc1ccccc1

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ MET P08581 12/20 0.41
▸ RET P07949 1/20 0.39
▸ KDR P35968 3/20 0.38
▸ DHODH Q02127 2/20 0.38
▸ LCK P06239 1/20 0.38
▸ AXL P30530 7/20 0.38
▸ MERTK Q12866 6/20 0.38
▸ PDGFRA P16234 2/20 0.37
▸ PDGFRB P09619 1/20 0.37
▸ SRC P12931 1/20 0.36
▸ TGFBR1 P36897 1/20 0.36
▸ KIT P10721 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzylamine SCHEMBL6004230 0.87 MET (0.41) METRETKDRLCKAXL
Beclamide SCHEMBL6004863 0.83 MET (0.43) METRETKDRDHODHLCK
Benzylamine SCHEMBL6004866 0.69 KDR (0.46) METKDRLCKAXLMERTK
SCHEMBL6002935 0.64 SRC (0.48) METKDRLCKAXLPDGFRA
SCHEMBL6004924 0.63 KDR (0.57) METRETKDRLCKAXL
SCHEMBL5312782 0.62 ADORA3 (0.51) DHODH
SCHEMBL1877252 0.62 PDGFRA (0.70) METKDRAXLPDGFRAKIT
SCHEMBL6004737 0.61 SRC (0.48) METKDRLCKAXLPDGFRA
SCHEMBL4401086 0.61 PDGFRA (0.71) METKDRLCKAXLPDGFRA
SCHEMBL29693541 0.61 PDGFRA (0.71) METKDRLCKAXLPDGFRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1724268-A1 COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME KIRIN BEER KABUSHIKI KAISHA (JP) 2006-11-22 — — EP disclosed