Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 3/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.50 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | MST1R | Q04912 | 1/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3906631 | 0.88 | TGFBR1 (0.53) | PDGFRBPDGFRASRCTGFBR1FGFR2 | |
| SCHEMBL6002914 | 0.85 | PDGFRB (0.49) | PDGFRBPDGFRASRCTGFBR1MET | |
| SCHEMBL3894620 | 0.85 | PDGFRB (0.49) | PDGFRBPDGFRASRCTGFBR1FGFR2 | |
| SCHEMBL3892235 | 0.83 | SRC (0.51) | PDGFRBPDGFRASRCTGFBR1KDR | |
| SCHEMBL3898480 | 0.82 | TGFBR1 (0.56) | PDGFRBPDGFRASRCTGFBR1FGFR2 | |
| SCHEMBL6005260 | 0.81 | MET (0.50) | SRCTGFBR1METKDRMST1R | |
| SCHEMBL3894336 | 0.81 | SRC (0.49) | PDGFRBPDGFRASRCTGFBR1KDR | |
| SCHEMBL3895419 | 0.80 | L3MBTL1 (0.46) | TGFBR1 | |
| SCHEMBL6004880 | 0.79 | TGFBR1 (0.52) | SRCTGFBR1METKDRMST1R | |
| SCHEMBL6004708 | 0.79 | TGFBR1 (0.52) | SRCTGFBR1METKDRMST1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |