Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 12/20 | 0.48 |
| ▸ | KDR | P35968 | 4/20 | 0.48 |
| ▸ | AURKA | O14965 | 3/20 | 0.48 |
| ▸ | TEK | Q02763 | 3/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | PRKACG | P22612 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6005261 | 0.92 | KDM4E (0.49) | KDM4EALDH1A1SMN1; SMN2KDRCYP3A4 | |
| SCHEMBL3895779 | 0.87 | FGFR2 (0.53) | KDRFGFR2PDGFRA | |
| SCHEMBL6004276 | 0.85 | LMNA (0.39) | ALDH1A1SMN1; SMN2KDRCYP3A4PDGFRA | |
| SCHEMBL6004765 | 0.84 | FGFR2 (0.45) | KDRFGFR2PDGFRA | |
| SCHEMBL6004093 | 0.83 | MET (0.45) | METKDRFGFR2PDGFRA | |
| SCHEMBL6005276 | 0.83 | SRC (0.44) | KDRFGFR2PDGFRA | |
| SCHEMBL6002948 | 0.83 | FGFR2 (0.47) | KDRFGFR2PDGFRA | |
| SCHEMBL6004812 | 0.83 | FGFR2 (0.44) | METKDRFGFR2PDGFRA | |
| SCHEMBL6004321 | 0.83 | FGFR2 (0.44) | KDRFGFR2PDGFRA | |
| SCHEMBL6004849 | 0.83 | MET (0.45) | METKDRFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |