Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | TOP1 | P11387 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004728 | 0.91 | CYP1A2 (0.37) | LMNAHPGDDHODHCYP3A4BRAF | |
| SCHEMBL6002787 | 0.88 | CCNC (0.39) | DHODHBRAFNPC1 | |
| SCHEMBL6004327 | 0.88 | TOP1 (0.42) | LMNADHODHNPC1TOP1ALDH1A1 | |
| SCHEMBL6005302 | 0.87 | DHODH (0.39) | DHODHTOP1ALDH1A1 | |
| SCHEMBL6004803 | 0.86 | FGFR2 (0.36) | DHODHADORA2ANPC1PDGFRBPDGFRA | |
| SCHEMBL6004795 | 0.86 | FGFR2 (0.36) | DHODHNPC1TOP1KDR | |
| SCHEMBL6004736 | 0.85 | KDM4E (0.48) | SMN1; SMN2CYP3A4ALDH1A1PDGFRAKDR | |
| SCHEMBL6005261 | 0.85 | KDM4E (0.49) | LMNAHPGDSMN1; SMN2CYP3A4TOP1 | |
| SCHEMBL3895779 | 0.85 | FGFR2 (0.53) | PDGFRBPDGFRAKDR | |
| SCHEMBL6005353 | 0.84 | CCNC (0.40) | DHODHBRAFTOP1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |